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ProteomicsA Polyamine-mediated Posttranslational Modification Required For Macrophage Tissue Residency – Differential proteome analysis of DHPS deficient macrophages
Tissue resident macrophages (MTRs) regulate tissue repair and homeostasis by clearing cell debris, and are thought to form the first line of defense against pathogens. MTRs form early in life and self-renew locally. However, during tissue damage or disease, bone-marrow derived monocytes enter tissue...
ORGANISM(S): Mus musculus (Mouse) 
2026-03-23 | PXD054670 | Pride
Eif5a Dia Spectronaut Dda spectral library Tissue resident macrophage proteomics Maxquant Label-free quantification Deoxyhypusine synthase (dhps) Hypusine 
ProteomicsM.musculus - T cell, SC (Hukelmannetal,natimmunol2016)
abundance based on Spectral counting, Interaction consistency score: 16.2, Coverage: 30
ORGANISM(S): 10090 
2016-00-00 | 190918057 | PAXDB
UnknownTrained immunity of alveolar macrophages requires metabolic rewiring and type 1 interferon signaling.
Not available
S-EPMC9385480 | biostudies-literature
ProteomicsLKB1/STK11-sensing of mitochondrial function controls Th17 cell responses
T helper 17 (Th17) cells are a distinct subset of CD4+ T cells necessary for maintaining gut homeostasis and have prominent roles in autoimmunity and inflammation. Th17 cells have unique metabolic features, including a stem cell-like signature and reliance on mitochondrial respiratory chain function...
ORGANISM(S): Mus musculus (Mouse) 
2022-10-13 | PXD036162 | Pride
Dia Spectronaut Th17 t cells Serine/threonine kinase liver associated kinase b1 (lkb1/stk11). Opa1 knock out th17 cells 
ProteomicsPolyamines and eIF5A hypusination modulate mitochondrial respiration and macrophage activation
How cells adapt metabolism to meet demands is an active area of interest across biology. Amongst a broad range of functions, the polyamine spermidine is needed to hypusinate the translation factor eukaryotic initiation factor 5A (eIF5A). We show here that hypusinated eIF5A (eIF5AH) promotes the effi...
ORGANISM(S): Mus musculus (Mouse) 
2019-05-24 | PXD013443 | Pride
Proteomics Macrophage Polyamine Eif5a 
UnknownPolyamine metabolism is a central determinant of helper T cell lineage fidelity.
Not available
S-EPMC8358979 | biostudies-literature
UnknownAn LKB1-mitochondria axis controls TH17 effector function.
Not available
S-EPMC9844518 | biostudies-literature
UnknownPolyamines and eIF5A Hypusination Modulate Mitochondrial Respiration and Macrophage Activation.
Not available
S-EPMC6688828 | biostudies-literature
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