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ProteomicsLocal GTP availability is an essential step in regulation of RAC1 activity and cell invasion
Physiological changes in GTP levels in live cells have never been considered a regulatory step of RAC1 activation because GTP concentrations determined by chromatography or mass spectrometry were shown to be substantially higher than the RAC1 GTP dissociation constant (RAC1-GTP Kd) determined in vit...
ORGANISM(S): Homo sapiens (Human) 
2021-11-04 | PXD028540 | Pride
Gtp sensors Impdh2 Rac1 Gtp 
UnknownInternally ratiometric fluorescent sensors for evaluation of intracellular GTP levels and distribution.
Not available
S-EPMC5636219 | biostudies-literature
UnknownCompartmentalization and regulation of GTP in control of cellular phenotypes.
Not available
S-EPMC9420775 | biostudies-literature
UnknownThe Lipid Kinase PI5P4Kβ Is an Intracellular GTP Sensor for Metabolism and Tumorigenesis.
Not available
S-EPMC4747657 | biostudies-literature
UnknownHighly Selective Fluorescent Sensors: Polyethylenimine Derivatives of Triphenylamine and Coumarin for GTP and ATP Interaction via Fluorescence Lifetime Imaging Microscopy.
Not available
S-EPMC10426326 | biostudies-literature
UnknownThe structure of the pleiotropic transcription regulator CodY provides insight into its GTP-sensing mechanism.
Not available
S-EPMC5100569 | biostudies-literature
UnknownESIPT fluorescence turn-on sensors for detection of short chain inorganic polyphosphate in water.
Not available
S-EPMC11665774 | biostudies-literature
UnknownGenetically encoded sensors of protein hydrodynamics and molecular proximity.
Not available
S-EPMC4443326 | biostudies-literature
UnknownMembrane Guanylate Cyclase catalytic Subdomain: Structure and Linkage with Calcium Sensors and Bicarbonate.
Not available
S-EPMC5461267 | biostudies-literature
ProteomicsSingle-cell signaling analysis reveals that Major Vault Protein facilitates RasG12C inhibitor resistance
Recently developed covalent inhibitors for RasG12C provide the first pharmacological tools to target mutant Ras-driven cancers. However, the rapid development of resistance to current clinical Ras G12C inhibitors is common. Presumably, a subpopulation of RasG12C-expressing cells adapt their signalin...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2024-05-16 | MSV000094779 | MassIVE
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