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GenomicsIMPDH2 filaments protect from neurodegeneration in AMPD2 deficiency
IMPDH2 filaments protect from neurodegeneration in AMPD2 deficiency
PRJNA1063698 | ENA
ProteomicsLocal GTP availability is an essential step in regulation of RAC1 activity and cell invasion
Physiological changes in GTP levels in live cells have never been considered a regulatory step of RAC1 activation because GTP concentrations determined by chromatography or mass spectrometry were shown to be substantially higher than the RAC1 GTP dissociation constant (RAC1-GTP Kd) determined in vit...
ORGANISM(S): Homo sapiens (Human) 
2021-11-04 | PXD028540 | Pride
Gtp sensors Impdh2 Rac1 Gtp 
ProteomicsNuclear IMPDH2 controls the DNA damage response by modulating PARP1 activity
Recent studies have highlighted the critical role of metabolism in the response to DNA damage. However, the precise metabolic interactions that are set in motion to tune this fundamental process remain largely unknown. In this study, we investigated the role of nuclear metabolism in the DNA damage r...
ORGANISM(S): Homo sapiens (Human) 
2024-11-28 | PXD043522 | Pride
Proteomics Parp1 Impdh2 Dna damage 
GenomicsNuclear IMPDH2 controls the DNA damage response by modulating PARP1 activity
Nuclear IMPDH2 controls the DNA damage response by modulating PARP1 activity
PRJNA1130837 | ENA
ProteomicsCytosolic EZH2-IMPDH2 complex regulates melanoma progression and metastasis via GTP regulation
The enhancer of zeste homolog 2 (EZH2) oncoprotein is a histone methyltransferase that functions canonically as a catalytic subunit of the polycomb repressive complex 2 (PRC2) to tri-methylate histone H3 at Lys 27 (H3K27me3). Although targeting EZH2 methyltransferase is a promising therapeutic strat...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2026-07-05 | PXD030100 | Pride
Actomyosin contractility Impdh2 Ribosome biogenesis Melanoma Gtp metabolism Ezh2 Sappanone a 
TranscriptomicsIMPDH2 filaments protect from neurodegeneration in AMPD2 deficiency
Metabolic dysregulation is one of the most common causes of pediatric neurodegenerative disorders. However, how the disruption of ubiquitous and essential metabolic pathways predominantly affect neural tissue remains unclear. Here we use a mouse model of AMPD2 deficiency to study cellular and molecu...
ORGANISM(S): Mus musculus 
2024-01-16 | GSE253045 | GEO
TranscriptomicsNuclear IMPDH2 controls the DNA damage response by modulating PARP1 activity
Nuclear metabolism and DNA damage response are intertwined processes, but the precise molecular connections remain elusive. Here, we delve into this crosstalk using as a model triple-negative breast cancer (TNBC), a subtype often prone to DNA damage accumulation. We reveal that the de novo purine sy...
ORGANISM(S): Homo sapiens 
2024-09-16 | GSE271269 | GEO
GenomicsEffect of deletion of Impdh2 on gene expression in the forlimbs from E12.5 embryos and osteoclasts (OCs)
Effect of deletion of Impdh2 on gene expression in the forlimbs from E12.5 embryos and osteoclasts (OCs)
PRJNA1021171 | ENA
UnknownIMPDH2 filaments protect from neurodegeneration in AMPD2 deficiency.
Not available
S-EPMC10849482 | biostudies-literature
GenomicsInosine Monophosphate Dehydrogenase 2 (IMPDH2) Modulates Response to Therapy and Chemo-Resistance in Triple Negative Breast Cancer
Inosine Monophosphate Dehydrogenase 2 (IMPDH2) Modulates Response to Therapy and Chemo-Resistance in Triple Negative Breast Cancer
PRJNA1101442 | ENA
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