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MetabolomicsIntegrating two chromatographies in a co-fractionation mass spectrometry approach improved protein-metabolite interactions (PMIs) mapping capabilities and revealed novel protein-ligand pairings in Escherichia coli.
The protein-metabolite interactome remains understudied. We previously developed a co-fractionation mass-spectrometry-based approach called PROMIS to address this gap. PROMIS relies on size separation chromatography of protein-metabolite complexes from lysates, followed by proteomics and metabolomic...
2025-04-25 | MTBLS9098 | MetaboLights
TranscriptomicsDistinctive responses to nitrogen starvation in the dominant active mutants of the fission yeast Rheb GTPase.
Rheb, a ras-like small GTPase conserved from human to yeast, controls Tor kinase and plays a central role in regulation of cell growth depending on extracellular conditions. Fission yeast Rheb regulates amino acid uptake as well as response to nitrogen starvation. In this study we generated two muta...
ORGANISM(S): Schizosaccharomyces pombe 
2009-09-28 | E-GEOD-14626 | biostudies-arrayexpress
GenomicsG3BP2-KIT drives leukemia amenable to kinase inhibition in Ph-like ALL
We describe a patient with Ph-like ALL, in which leukemic cells harbored an in-frame fusion between the GTPase-activating protein (SH3 domain)-binding protein 2 (G3BP2) and the KIT proto-oncogene.
EGAS00001005181 | EGA
TranscriptomicsHuman-specific gene ARHGAP11B promotes basal progenitor amplification and neocortex expansion
The evolutionary expansion of the human neocortex reflects increased amplification of basal progenitors in the subventricular zone, producing more neurons during fetal corticogenesis. Here, we analyze the transcriptomes of distinct progenitor subpopulations isolated by a novel approach from developi...
ORGANISM(S): Homo sapiens 
2015-03-02 | E-GEOD-65000 | biostudies-arrayexpress
ProteomicsTMEM55B mediates lysosomal positioning via TBC1D9B, a GTPase-activating protein (GAP) for Arl8gb.
TMEM55B mediates lysosomal positioning via TBC1D9B, a GTPase-activating protein (GAP) for Arl8gb.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2024-08-23 | MSV000095685 | MassIVE
TranscriptomicsBeta-tubulin and Actin Filament-Associating Small GTPase GIMAP4 is Required for IFN-Ɣ Secretion During Early Human CD4+ T Cell Activation
The aim of the dataset was to study on a genome-wide level the effect of GTPase of the human immune associated protein 4 (GIMAP4) knockdown on the gene expression of resting T cells and immediately after T cell activation and Th1(Act+IL12) polarizing conditions of human cord blood-derived CD4+ T cel...
ORGANISM(S): Homo sapiens 
2014-10-09 | E-GEOD-45720 | biostudies-arrayexpress
GenomicsDysregulation of GTPase-activating protein-binding protein1 in the pathogenesis of metabolic dysfunction-associated steatotic liver disease
Dysregulation of GTPase-activating protein-binding protein1 in the pathogenesis of metabolic dysfunction-associated steatotic liver disease
PRJNA1301331 | ENA
UnknownThe Arf GTPase-activating protein ASAP1 regulates the actin cytoskeleton.
Not available
S-EPMC18133 | biostudies-literature
UnknownSolution structure and dynamics of the mitochondrial-targeted GTPase-activating protein (GAP) VopE by an integrated NMR/SAXS approach.
Not available
S-EPMC9047041 | biostudies-literature
GenomicsNKX3-1, a Novel Transcriptional Factor of AR, Promotes Prostate Cancer Cell Survival via RAB3B GTPase-mediated protein trafficking
Androgen receptor (AR) orchestrates an intricate transcriptional regulatory network that governs prostate cancer initiation, development and progression. To understand this network in detail, we generated genome-wide maps of AR occupancy by ChIP-seq in LNCaP cells. We found NKX3-1, an androgen-depen...
ORGANISM(S): Homo sapiens 
2011-11-16 | E-GEOD-28264 | biostudies-arrayexpress
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