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ProteomicsHuman GTPBP5 is involved in the late stage of mitoribosome large subunit assembly
Human mitoribosomes are macromolecular complexes essential for translation of 11 mitochondrial mRNAs. The large and the small mitoribosomal subunits undergo a multistep maturation process that requires the involvement of several factors. Among these factors, GTP-binding proteins (GTPBPs) play an imp...
ORGANISM(S): Homo sapiens (Human) 
2020-11-09 | PXD017384 | Pride
Mitochondria Silac Lfq 
UnknownHuman GTPBP5 (MTG2) fuels mitoribosome large subunit maturation by facilitating 16S rRNA methylation.
Not available
S-EPMC7430652 | biostudies-literature
UnknownHuman GTPBP5 is involved in the late stage of mitoribosome large subunit assembly.
Not available
S-EPMC7797037 | biostudies-literature
ProteomicsGTPase driven maturation of the human mitoribosomal peptidyl transferase center
We combine genetic perturbation with cryo-electron microscopy (cryo-EM) to establish the mechanism of PTC maturation during human mitoribosome biogenesis. Cryo-EM structures of large mitoribosomal subunit (mtLSU) assembly intermediates purified from GTPBP6-deficient cells reveal that GTPBP5 acts in ...
ORGANISM(S): Homo sapiens (Human) 
2021-05-20 | PXD023502 | Pride
Ptc maturation Gtpbp5 Gtpbp6 Mitochondrial ribosome Ribosome recycling Ribosome assembly Mterf4-nsun4 Mitoribosome Obg-hflx superfamily 
UnknownStructural basis for late maturation steps of the human mitoribosomal large subunit.
Not available
S-EPMC8209036 | biostudies-literature
UnknownStructural basis of GTPase-mediated mitochondrial ribosome biogenesis and recycling.
Not available
S-EPMC8209004 | biostudies-literature
UnknownGenome-Wide Knockout Screen Identifies EGLN3 Involving in Ammonia Neurotoxicity.
Not available
S-EPMC9001847 | biostudies-literature
UnknownMTG2 as a Causal and Druggable Target in Uveal Melanoma via Mitochondrial DNA Dynamics: Evidence From Functional Validation and DMSA Identification.
Not available
S-EPMC12908717 | biostudies-literature
TranscriptomicsADRM1 amplified metastasis gene in gastric cancer
Selected genes within the 1 Mb minimal amplified region on 20q13.3 driven by ADRM1 in gastric cancer cell line AGS were analyzed by Gene expression Microarray. Gene Expression of ADRM1, HRH3, MTG2, LAMA5 and OSBPL2 were then compared in 16 Gastric cancer cell lines to a reference composed of mixed g...
ORGANISM(S): Homo sapiens 
2015-01-01 | E-GEOD-64604 | biostudies-arrayexpress
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