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ProteomicsGTPase driven maturation of the human mitoribosomal peptidyl transferase center
We combine genetic perturbation with cryo-electron microscopy (cryo-EM) to establish the mechanism of PTC maturation during human mitoribosome biogenesis. Cryo-EM structures of large mitoribosomal subunit (mtLSU) assembly intermediates purified from GTPBP6-deficient cells reveal that GTPBP5 acts in ...
ORGANISM(S): Homo sapiens (Human) 
2021-05-20 | PXD023502 | Pride
Ptc maturation Gtpbp5 Gtpbp6 Mitochondrial ribosome Ribosome recycling Ribosome assembly Mterf4-nsun4 Mitoribosome Obg-hflx superfamily 
UnknownStructural basis of GTPase-mediated mitochondrial ribosome biogenesis and recycling.
Not available
S-EPMC8209004 | biostudies-literature
UnknownDysregulation of X-linked gene expression in Klinefelter's syndrome and association with verbal cognition.
Not available
S-EPMC2094046 | biostudies-literature
UnknownMechanisms of ribosome recycling in bacteria and mitochondria: a structural perspective.
Not available
S-EPMC9067457 | biostudies-literature
UnknownX chromosome dosage and the genetic impact across human tissues.
Not available
S-EPMC10053618 | biostudies-literature
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