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Biosynthesis of mitochondrial genome-encoded proteins is carried out by the mitoribosome, a specialized apparatus that has evolved and diverged dramatically since its bacterial origin. Recent studies across various eukaryotes have demonstrated widespread structural and compositional diversity of mit...
ORGANISM(S): Diplonema papillatum 
2023-05-19 | PXD039882 | Pride
The human mitochondrial ribosome contains three [2Fe-2S] clusters whose assembly pathway, role, and implications for mitochondrial and metabolic diseases are unknown. Here, structure-function correlation studies show that the clusters play structural roles during mitoribosome assembly. To uncover th...
ORGANISM(S): Homo sapiens (Human) 
2024-01-26 | PXD039321 | Pride
Biosynthesis of mitochondrial genome-encoded proteins is carried out by the mitoribosome, a specialized apparatus that has evolved and diverged dramatically since its bacterial origin. Recent studies across various eukaryotes have demonstrated widespread structural and compositional diversity of mit...
ORGANISM(S): Diplonema papillatum 
2023-05-19 | PXD039927 | Pride
Biosynthesis of mitochondrial genome-encoded proteins is carried out by the mitoribosome, a specialized apparatus that has evolved and diverged dramatically since its bacterial origin. Recent studies across various eukaryotes have demonstrated widespread structural and compositional diversity of mit...
ORGANISM(S): Diplonema papillatum 
2023-10-24 | PXD040176 | Pride
NDUFAB1 is the mitochondrial acyl carrier protein (ACP) essential for cell viability. Through its pantetheine-4’-phosphate post-translational modification, NDUFAB1 interacts with members of the leucine-tyrosine-arginine motif (LYRM) protein family. Although many LYRM proteins have been well describe...
ORGANISM(S): Homo sapiens (Human) 
2019-10-31 | PXD013706 | Pride
Mitochondrial gene expression relies on mitoribosomes to translate mitochondrial mRNAs. The biogenesis of mitoribosomes is an intricate process involving multiple assembly factors. Among these factors, GTP-binding proteins (GTPBPs) play crucial roles. In bacterial systems, numerous GTPBPs are requir...
ORGANISM(S): Homo sapiens (Human) 
2024-04-11 | PXD045264 | Pride
GTPBP8 is essential for mitoribosome formation in human mitochondria
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