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ProteomicsPBRM1 loss in kidney cancer imbalances the proximal tubule master transcription factor hub to repress proximal tubule differentiation
PBRM1 is the 2nd-most frequently inactivated gene in clear cell renal cell cancer (RCC) but the oncogenic mechanisms, and hence methods for correction, are unclear. PBRM1 is a subunit of the PBAF coactivator complex that transcription factors use to reposition nucleosomes (‘open chromatin’) for gene...
ORGANISM(S): Homo sapiens (Human) 
2022-02-16 | PXD020544 | Pride
Pbrm1 pax8 differentiation 
ProteomicsMolecular and clinical analyses of PHF6 mutant myeloid neoplasia provide clues as to their pathogenesis and therapeutic targeting
PHF6 mutations (PHF6MT) are identified in various myeloid neoplasms (MN). However, little is known about the precise function and consequences of PHF6 in MN. Our comprehensive genomic analyses focused on three main findings. Firstly, we revealed a different pattern of genes correlating with PHF6MT i...
ORGANISM(S): Homo sapiens (Human) 
2023-11-21 | PXD042441 | Pride
Human Lc-msms Phf6 Aml 
TranscriptomicsTranscription profiling of human normal and cadaver primary open-angle glaucoma donors
The total RNA from control and POAG optic nerve lamina cribrosa region was isolated and subjected to analysis on U133A 2.0 affymetrix microarray chip. The results from these two analysis was compared to determine whether PAD II RNA level is altered. Purpose of the study. This study was done to dete...
ORGANISM(S): Homo sapiens 
2008-06-12 | E-GEOD-2387 | biostudies-arrayexpress
ProteomicsTandem proteomic and N-glycoproteomic analysis of extracellular vesicles
Extracellular vesicles (EVs) derived from diverse biofluids have emerged as promising noninvasive diagnostic biomarkers or signatures for various diseases. EV-associated N-glycoproteins are crucial for the biological functions of EVs and hold significant potential for disease diagnosis and prognosis...
ORGANISM(S): Homo Sapiens 
2024-11-05 | PXD057512 |
Proteomicsproteomic and N-glycoproteomic analysis of extracellular vesicles for biofluids
Extracellular vesicles (EVs) derived from diverse biofluids have emerged as promising noninvasive diagnostic biomarkers or signatures for various diseases. EV-associated N-glycoproteins are crucial for the biological functions of EVs and hold significant potential for disease diagnosis and prognosis...
ORGANISM(S): Homo Sapiens 
2024-11-05 | PXD057515 |
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