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ProteomicsMolecular and clinical analyses of PHF6 mutant myeloid neoplasia provide clues as to their pathogenesis and therapeutic targeting
PHF6 mutations (PHF6MT) are identified in various myeloid neoplasms (MN). However, little is known about the precise function and consequences of PHF6 in MN. Our comprehensive genomic analyses focused on three main findings. Firstly, we revealed a different pattern of genes correlating with PHF6MT i...
ORGANISM(S): Homo sapiens (Human) 
2023-11-21 | PXD042441 | Pride
Human Lc-msms Phf6 Aml 
GenomicsRNA sequencing of isogenic Phf6 wild type and Phf6 knockout mouse T-ALL cells
RNA sequencing of isogenic Phf6 wild type and Phf6 knockout mouse T-ALL cells
PRJNA481336 | ENA
GenomicsRNA-seq profiling of HSC, MPPs and HPC-1s from Phf6-deleted and Phf6-intact mice
RNA-seq profiling of HSC, MPPs and HPC-1s from Phf6-deleted and Phf6-intact mice
PRJNA521533 | ENA
GenomicsGene expression in Phf6-deleted and Phf6-intact foetal mouse cortical neurons and foetal mouse cortex assessed by RNA-seq
Gene expression in Phf6-deleted and Phf6-intact foetal mouse cortical neurons and foetal mouse cortex assessed by RNA-seq
PRJNA1152848 | ENA
GenomicsTranscriptomic changes in PHF6 knockout THP1 human AML cell line on rescue with PHF6 wildtype (with and without PHIP) or rescue with PHF6R274Q mutant
Transcriptomic changes in PHF6 knockout THP1 human AML cell line on rescue with PHF6 wildtype (with and without PHIP) or rescue with PHF6R274Q mutant
PRJNA1184835 | ENA
GenomicsTranscriptomic changes in ER-HOXB8 mouse cell line on Phf6 knockout
Transcriptomic changes in ER-HOXB8 mouse cell line on Phf6 knockout
PRJNA1184836 | ENA
GenomicsGene regulation of PHF6 in mouse developing cortex
Gene regulation of PHF6 in mouse developing cortex
PRJNA490879 | ENA
GenomicsPHF6 OCCUPANCYIN HUMAN T-CELL ACUTE LYMPHOBLASTIC LEUKEMIA
Here we identify the genome-wide occupancy of PHF6 in T-ALL cells. Human T-ALL cells were cross-linked with formaldehyde for 20 min. DNA was enriched by chromatin immunoprecipitation (ChIP) and analyzed by Solexa sequencing. A sample of whole cell extract (WCE) was sequenced and used as the backgrou...
ORGANISM(S): Homo sapiens 
2014-04-01 | E-GEOD-45864 | biostudies-arrayexpress
TranscriptomicsRNA sequencing of isogenic Phf6 wild type and Phf6 knockout mouse T-ALL cells
Loss-of-function mutations Phf6 occur frequently in both adult and pediatric T-cell Acute Lymphoblastic Leukemia (T-ALL). Although Phf6 is widely expressed, little is known about its proposed function as epigenetic regulator and tumor suppressor. To address the role of Phf6 in the leukemia developme...
ORGANISM(S): Mus musculus 
2019-07-31 | GSE117165 | GEO
GenomicsChanges in H3K27 acetylation in THP1 human AML cell line on PHF6 knockout, PHF6R274Q mutation, PHIP knockout, and double knockout of PHF6 and PHIP compared to wildtype clones
Changes in H3K27 acetylation in THP1 human AML cell line on PHF6 knockout, PHF6R274Q mutation, PHIP knockout, and double knockout of PHF6 and PHIP compared to wildtype clones
PRJNA1184838 | ENA
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