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MetabolomicsAn LCMS-based untargeted metabolomics protocol for cochlear perilymph: highlighting metabolic effects of hydrogen gas on the inner ear of noise exposed Guinea pigs

INTRODUCTION: Noise-induced hearing loss (NIHL) is an increasing problem in society and accounts for a third of all cases of acquired hearing loss. NIHL is caused by formation of reactive oxygen species (ROS) in the cochlea causing oxidative stress. Hydrogen gas (H2) ...

2021-10-06 | MTBLS2418 | MetaboLights
ProteomicsCavia porcellus spectral library
The guinea pig (cavia porcellus) is an excellent experimental model for translation to many aspects of human physiology and disease yet there is limited experimental information regarding its proteome. In an effort to overcome this gap in our knowledge, we generated a comprehensive spectral library ...
ORGANISM(S): Cavia Porcellus (ncbitaxon:10141) 
2018-12-07 | MSV000083199 | MassIVE
ProteomicsProteomics analysis of guinea pig retina at the early stage of myopia
This is a combined SWATH database of early myopic guinea pig retina. The retinal tissues were divided into lens induced myopia 4 days group (4-day LIM) and control group; 5 individual animals (10 retinas) were included. The potential biomarkers and underlying biochemical pathways during early myopia...
ORGANISM(S): Cavia porcellus (Guinea pig) 
2021-05-13 | PXD025003 | Pride
Proteomics guinea pig retina myopia 
TranscriptomicsGene expression pattern after insertion of dexamethasone-eluting electrode into the guinea pig cochlea.
To investigate the effect of the dexamethasone-eluting electrode in the guinea pig cochlea, and compared the gene expression after 7 days insertion with that of a normal electrode or non-treated control by microarray. Male Hartley guinea pigs (SLC, Shizuoka, Japan) with an age of seven weeks were us...
ORGANISM(S): Cavia porcellus 
2014-01-17 | E-GEOD-53866 | biostudies-arrayexpress
ProteomicsQuantitative Proteomics of Cochlear Tissues: Bilateral Comparisons in Guinea Pigs and Rats
The cochlea, a sensitive biosensor, detects sound waves and converts them into electrical signals the brain recognizes as sound. Damage to cochlear hair cells can release proteins, triggering biological responses that may impair hearing. Mass spectrometry-based proteomics offers insights into protei...
ORGANISM(S): Cavia porcellus (Guinea pig) Rattus norvegicus (Rat) 
2025-07-21 | PXD059025 | Pride
Mass-spectrometry Cochlear tissue Rat Proteomics Guinea pigs 
TranscriptomicsDevelopment of oligonucleotide microarray to study global gene expression profile in guinea pigs in response to tuberculosis infection
In this study we developed a guinea pig oligonucleotide microarray (GPOM) comprising of a total number of 45,220 features including 43,803 valid features from different mammalian species. These features are inclusive of 2971 newly annotated probes corresponding to 344 unique genes of guinea pig. As ...
ORGANISM(S): Cavia porcellus 
2012-10-01 | E-GEOD-32447 | biostudies-arrayexpress
ProteomicsIntegrated Omic Analysis of a Guinea Pig Model of Heart Failure and Sudden Cardiac Death
Here we examine key regulatory pathways underlying the transition from compensated hypertrophy (HYP) to decompensated heart failure (HF) and sudden cardiac death (SCD) in a guinea pig model by integrated multi-ome analysis. Relative protein abundances from sham-operated, HYP and HF hearts were asses...
ORGANISM(S): Cavia porcellus (Guinea pig) 
2018-10-26 | PXD003980 | Pride
Heart Proteomics Cardiac Itraq 
ProteomicsProteomic study of the retina of guinea pigs with form-deprivation myopia
Myopia has become the major cause of visual impairment worldwide. However, its retina-related pathogenesis remains unclear. In recent years, proteomics has become a high-throughput tool to explain biological mechanisms. In this study, we examined the retinas of guinea pigs with form deprivation myop...
ORGANISM(S): Cavia porcellus (Guinea pig) 
2023-07-12 | PXD043226 | Pride
Guinea pig Proteome Retina 
GenomicsGuinea pig major allergen
mRNA coding for major guinea pig isoallergens of Cav p 1
PRJEB31026 | ENA
TranscriptomicsDifferential virulence gene expression in the pathogenic dermatophyte Arthroderma benhamiae in vitro versus infection
Although dermatophytes are the most common agents of superficial mycoses in humans and animals, the molecular basis of the pathogenicity of these fungi is largely unknown. In vitro digestion of keratin by dermatophytes is associated with the secretion of multiple proteases, which are assumed to be r...
ORGANISM(S): Arthroderma benhamiae 
2010-03-04 | E-GEOD-15873 | biostudies-arrayexpress
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