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MetabolomicsDifferential role of sphingomyelin in influenza virus, rhinovirus and SARS-CoV-2 infection of Calu-3 cells
Host cell lipids play a pivotal role in the pathogenesis of respiratory virus infection. However, a direct comparison of the lipidomic profile of influenza virus and rhinovirus infections is lacking. In this study, we first compared the lipid profile of influenza virus and rhinovirus infection in a ...
2022-11-15 | MTBLS2352 | MetaboLights
UnknownElements between the IgH variable (V) and diversity (D) clusters influence antisense transcription and lineage-specific V(D)J recombination.
Not available
S-EPMC3009784 | biostudies-literature
ProteomicsDevelopment and characterization of selective FAK inhibitors and PROTACs with in vivo activity
Focal adhesion kinase (FAK) is an attractive drug target due to its overexpression in cancer. FAK functions as a non-receptor tyrosine kinase and scaffolding protein, coordinating several downstream signaling effectors and cellular processes. While drug discovery efforts have largely focused on targ...
ORGANISM(S): Homo sapiens (Human) 
2025-05-06 | PXD039828 | Pride
Fak Inhibitor Protac Degrader 
UnknownFrom genome to drug lead: identification of a small-molecule inhibitor of the SARS virus.
Not available
S-EPMC7119130 | biostudies-literature
UnknownIntegrated Genetic Analysis of Racial Differences of Common GBA Variants in Parkinson's Disease: A Meta-Analysis.
Not available
S-EPMC5829555 | biostudies-literature
UnknownDlg5 maintains apical polarity by promoting membrane localization of Crumbs during Drosophila oogenesis.
Not available
S-EPMC4876392 | biostudies-literature
MetabolomicsRed-Fleshed Apple Anthocyanin Extracts Attenuate Male Reproductive System Dysfunction Caused by Busulfan in Mice (Mouse blood plasma; UPLC-MS/MS assays)

In this research, we analyzed the effect of oral administration of red-fleshed apple anthocyanin extract (RAAE) on busulfan-treated mice. At first, we showed that the most abundant component in RAAE was cyanidin 3-O-galactoside. To determine the effect of RAAE, mice were divided into control and ...

2021-06-07 | MTBLS2782 | MetaboLights
UnknownUnited States State-Level Variation in the Use of Neuraxial Analgesia During Labor for Pregnant Women.
Not available
S-EPMC6324365 | biostudies-literature
TranscriptomicsInduction of 1C Aldoketoreductases and Other Drug Dose-dependent Genes Upon Acquisition of Anthracycline Resistance
Recent studies have suggested that elevated expression of aldoketoreductase (AKR) 1C1 or 1C2 in tumour cells is associated with increased resistance to DNA damaging agents such as cisplatin and doxorubicin. However, it has not been shown whether selection of tumour cells for resistance to DNA-damag...
ORGANISM(S): Homo sapiens 
2008-07-16 | E-GEOD-12115 | biostudies-arrayexpress
UnknownALDH2 protects against stroke by clearing 4-HNE.
Not available
S-EPMC3698638 | biostudies-literature
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