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UnknownCryo electron microscopy micrographs of yeast Exocyst complex
Not available
EMPIAR-10206 | biostudies-other
ProteomicsTargeting PILRα, an immune checkpoint mediating T cell suppression, for cancer immunotherapy
One of the most successful therapies in cancer treatment involves immune checkpoint blockade using the anti-programmed death-1 (anti-PD-1)/programmed death-ligand 1 (PD-L1) antibody, which targets the interaction between tumors and T cells. However, the overall response rate is < 30% in patients wit...
ORGANISM(S): Homo Sapiens 
2024-01-25 | PXD048903 |
UnknownSystematic profiling of SARS-CoV-2-specific IgG responses elicited by an inactivated virus vaccine identifies peptides and proteins for predicting vaccination efficacy.
Not available
S-EPMC8367966 | biostudies-literature
UnknownLinear epitope landscape of the SARS-CoV-2 Spike protein constructed from 1,051 COVID-19 patients.
Not available
S-EPMC7953450 | biostudies-literature
Proteomicsm6A binding proteins identified by SPIDER assay
To assess whether SPIDER could identify modified nucleic acids binding proteins within a complex environment, such as the cellular milieu, we sought to identify N6-methyladenosine (m6A) binding proteins within a total cell lysate. We performed SPIDER assay by incubating biotin-ssRNAs（with and withou...
ORGANISM(S): Homo Sapiens 
2022-11-02 | PXD026519 |
ProteomicsLenalidomide binding proteins identified by SPIDER assay
To assess whether SPIDER could capture protein-small molecule interaction in a complex environment, here we carried out the SPIDER assay by incubating biotin-Lenalidomide or a biotin control with HEK293T total lysate, followed by the use of biotin conjugated beads coupled with mass spectrometry to i...
ORGANISM(S): Homo Sapiens 
2021-06-04 | PXD026523 |
ProteomicsPupylation sites on protein Sox2
As a test for the effectiveness of SPIDER with RNA-protein pairs, We used Sox2 and specific biotin-DNA and biotin-RNA to validate the efficiency of SPIDER capturing protein-nucleic acid interaction. Pupylation sites on Sox2 after SPIDER assay was identified by LC-MS/MS analysis, by searching for an ...
ORGANISM(S): Homo Sapiens 
2021-06-04 | PXD026517 |
ProteomicsPupylation sites on SARS-CoV-2 N
As a test for the effectiveness of SPIDER with RNA-protein pairs, we examined SARS-CoV-2 Nucleoprotein. We used Nucleoprotein and specific biotin-RNA to validate the efficiency of spider capturing N and analysised the pupylation sites of N protein by mass spectrometry
ORGANISM(S): Severe Acute Respiratory Syndrome Coronavirus 2 
2021-06-04 | PXD026518 |
ProteomicsmRNA-protein interactome of THP-1 cells
To investigate the effectiveness of SPIDER identifying the mRNA interactome, we carried out the SPIDER assay by incubating biotin-oligo(dT) or biotin control directly with cell lysates of THP-1 cells
ORGANISM(S): Homo Sapiens 
2021-06-04 | PXD026521 |
Proteomicsm6A binding proteins identidified by RNA pull down.
Biotinyted nucleic acid probe assay for protein-m6A interaction
ORGANISM(S): Escherichia Coli 
2022-11-02 | PXD037881 |
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