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TranscriptomicsRNA-seq of Nicotiana benthamiana infected with wild-type and mutant Asparagus Virus 2
Nicotiana benthamiana plants were infected with Asparagus Virus 2 and its mutant version. Upper non-inoculated leaves were collected at various time points and used for sample preparation. RNA-seq was performed on the WT infected, mutant infected and mock uninfected samples. Ribo-seq was performed o...
ORGANISM(S): Nicotiana benthamiana 
2024-05-07 | E-MTAB-13539 | biostudies-arrayexpress
TranscriptomicsInduction of 1C Aldoketoreductases and Other Drug Dose-dependent Genes Upon Acquisition of Anthracycline Resistance
Recent studies have suggested that elevated expression of aldoketoreductase (AKR) 1C1 or 1C2 in tumour cells is associated with increased resistance to DNA damaging agents such as cisplatin and doxorubicin. However, it has not been shown whether selection of tumour cells for resistance to DNA-damag...
ORGANISM(S): Homo sapiens 
2008-07-16 | E-GEOD-12115 | biostudies-arrayexpress
TranscriptomicsTranscriptome adaptation of group B Streptococcus to growth in human amniotic fluid
We have discovered that GBS significantly remodels its transcriptome in response to exposure to human amniotic fluid. A large number of the affected genes are of unknown function, which means that much remains to be learned about the full influence of amniotic fluid on GBS. The majority of the obse...
ORGANISM(S): Streptococcus agalactiae 
2010-05-18 | E-GEOD-14456 | biostudies-arrayexpress
ProteomicsQuantification of Raloxifene Specific 471 Da Adducts in CYP3A4 and P450-Reductase
Drugs are often metabolized to reactive intermediates that form protein adducts. Adducts can inhibit critical proteins, elicit immune responses, and cause life threatening adverse drug reactions. The masses of metabolites are frequently unknown, rendering traditional mass spectrometry-based proteomi...
ORGANISM(S): Homo Sapiens Rattus Norvegicus 
2022-02-21 | PXD024932 | panorama
TranscriptomicsLncRNAs expression profiles in the livers of 20-month-old male HBx transgenic mice and C57BL/6 wild-type mice
The hepatitis B virus X protein (HBx) has been implicated as an oncogene in both epigenetic modifications and genetic regulation during hepatocarcinogenesis, but the underlying mechanisms are not entirely clear. Long non-coding RNAs (lncRNAs), which regulate gene expression with little or no protein...
ORGANISM(S): Mus musculus 
2013-11-04 | E-GEOD-42185 | biostudies-arrayexpress
ProteomicsDetection and Quantification of Drug-Protein Adducts in Human Liver
Protein adducts formed by drugs or their reactive metabolites are risk factors for adverse reactions, toxicity and inactivation of cytochrome P450 (CYP) enzymes. Characterization of drug-protein adducts is limited due to lack of methods capable of discovering the proteins and peptides adducted by re...
ORGANISM(S): Homo Sapiens Spodoptera Frugiperda 
PXD054246 | panorama
TranscriptomicsTransition from succinate to methanol growth in Methylobacterium Extorquens AM1
In order to provide information about the gene expression response that occurs when cells experience a change in carbon source, succinate limited chemostat cultures of Methylobacterium extorquens AM1 were grown to and maintained at an OD of ~0.63, transferred to flasks and methanol was added. Cells...
ORGANISM(S): Methylobacterium extorquens AM1 
2011-07-31 | E-GEOD-22031 | biostudies-arrayexpress
ProteomicsA.thaliana - Root, SC (Zhangetal,scidata2019)
abundance based on Spectral counting, Interaction consistency score: 2.2, Coverage: 35
ORGANISM(S): 3702 
2019-00-00 | 1074583746 | PAXDB
TranscriptomicsAdaptation of group A Streptococcus to human amniotic fluid
Background. For more than 100 years, group A Streptococcus has been identified as a cause of severe, and in many cases fatal, infections of the female urogenital tract. Due to advances in hospital hygiene and the advent of antibiotics, this type of infection has been virtually eradicated. However, w...
ORGANISM(S): Streptococcus pyogenes MGAS6180 
2010-05-05 | E-GEOD-19985 | biostudies-arrayexpress
TranscriptomicsSplicing function of mitotic regulators links R-loop mediated DNA damage to tumor cell killing
We discovered that two mitotic regulators, BuGZ and Bub3, involved in splicing regulation during interphase 8 samples from primary Human foreskin fibroblast cells (HFFs) , 12 samples from TOV21G cells. Control siRNA. BuGZ siRNA or Bub3 siRNA were transfected for 48 h before sample collection. Cells ...
ORGANISM(S): Homo sapiens 
2015-04-11 | E-GEOD-67770 | biostudies-arrayexpress
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