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ProteomicsPGC7-interacting proteins in HEK293T cells
Primordial germ cell 7 (PGC7), a maternal factor essential for early development, plays a critical role in the regulation of DNA methylation, transcriptional repression, chromatin condensation, and cell division and the maintenance of cell pluripotentiality. Despite the fundamental roles of PGC7 in ...
ORGANISM(S): Homo sapiens (Human) 
2017-07-28 | PXD006362 | Pride
Pgc7 hek293t lc-ms/ms 
TranscriptomicsDeep sequencing identifies PD0325901 modulated microRNAs in the J1 mESCs
PD0325901 is involved in improving reprogramming efficiency during inducing pluripotent stem cells (iPSC) or maintain a blastocyst-like state in embryonic stem cells (ESC). However, the knowledge about this small molecule regulating miRNAs in ESC was limited. To understand the role of miRNAs during ...
ORGANISM(S): Mus musculus 
2016-05-17 | E-GEOD-67570 | biostudies-arrayexpress
TranscriptomicsIdentifying PD0325901-regulated genes in the J1 mESCs
It has been demonstrated that PD0325901 promotes self-renewal of mouse embryonic stem cells, however, the target genes of PD0325901 are not fully understood. To better understand the downstream target genes of PD0325901, we performed Microarray analyses to identify their downstream targets. The data...
ORGANISM(S): Mus musculus 
2016-05-17 | E-GEOD-67534 | biostudies-arrayexpress
ProteomicsProteomic Analysis of Foxc1-interacting proteins in HEK293T cells
Foxc1 has been identified to participate in regulating genes expression directly by binding their promoters as well as playing various roles in signal transduction within the cells. In this study, we found that, in F9 Embryonal Carcinoma cells, Foxc1 repressed the promoter’s transcription activity b...
ORGANISM(S): Homo sapiens (Human) 
2021-09-09 | PXD022178 | Pride
Foxc1 Lc-msms 
TranscriptomicsAICAR can modulate the expression of microRNA in J1 mESC
We have demonstrated AICAR can maintain J1 mouse ES cells pluripotency in our previous research, yet its effects on ES cells miRNAs expression remain a mystery. In this study, we performed small RNA (sRNA) High-throughput sequencing using Illumina HiSeq 2000 to investigate the influence of AICAR on ...
ORGANISM(S): Mus musculus 
2014-02-06 | E-GEOD-54586 | biostudies-arrayexpress
TranscriptomicsIdentifying vitamin C and RA-regulated genes in the J1 mESCs
It has been demonstrated that vitamin C enhances reprogramming efficiency during inducing pluripotent stem cells, however, the underlying mechanisms are not fully understood. To find the downstream target genes of vitamin C and investigate the mechanism of vitamin C on reprogramming promotion, we pe...
ORGANISM(S): Mus musculus 
2014-01-21 | E-GEOD-43405 | biostudies-arrayexpress
TranscriptomicsIdentifying CHIR99021 and AICAR-regulated genes in the J1 mESCs
It has been demonstrated that CHIR99021 promotes self-renewal of mouse embryonic stem cells, however, the target genes of CHIR99021 is not fully understood. AICAR is the activator of AMP-activated protein kinase. It is reported that AICAR plays important role in mouse embryonic stem cells, however t...
ORGANISM(S): Mus musculus 
2013-01-01 | E-GEOD-40959 | biostudies-arrayexpress
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