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ProteomicsProteomic Analysis of Foxc1-interacting proteins in HEK293T cells
Foxc1 has been identified to participate in regulating genes expression directly by binding their promoters as well as playing various roles in signal transduction within the cells. In this study, we found that, in F9 Embryonal Carcinoma cells, Foxc1 repressed the promoter’s transcription activity b...
ORGANISM(S): Homo sapiens (Human) 
2021-09-09 | PXD022178 | Pride
Foxc1 Lc-msms 
GenomicsFoxc1 IIBA ChIP-seq
Chromatin immunoprecipitation using Foxc1 antibodies in second branchial arch (IIBA) cells from E11.5 mouse embryos detected by SOLiD sequencing
ORGANISM(S): Mus musculus 
2015-02-02 | E-MTAB-2696 | biostudies-arrayexpress
ProteomicsConserved Role of FOXC1 in TNBC is parallel to FOXA1 in ER+ Breast Cancer
Triple-negative breast cancer (TNBC) is characterized by lack of receptors, estrogen (ER), progesterone, and Her2, and standard receptor-targeted therapies are ineffective. FOXC1, a transcriptional factor aberrantly overexpressed in many cancers, drives growth, metastasis, and stem-cell-like prope...
ORGANISM(S): Homo sapiens (Human) 
2024-07-03 | PXD053261 | Pride
Tumor suppressors Foxa1 Foxc1 Heterogeneity Gene regulation Oncogenes Chip-seq Triple-negative breast cancer Nr2f 
TranscriptomicsRNA-seq analysis of hair follicle stem cell transcriptome upon loss of the transcription factor FOXC1
We report downstream gene expression changes in stem cells of the adult mouse hair follicle upon conditional ablating of the transcription factor Forkhead Box C1 transcription factor (FOXC1). Hair follicles undergo cycles of rest (telogen; Tel) and regeneration (anagen; Ana). As such, we performed o...
ORGANISM(S): Mus musculus 
2016-02-16 | E-GEOD-77256 | biostudies-arrayexpress
TranscriptomicsFrequent derepression of the mesenchymal transcription factor gene in acute myeloid leukemia (mouse)
Murine CD45.1+ CD117+ BM cells were co-transduced pairwise with retroviral vectors expressing Hoxa9, Meis1, Foxc1 or a control empty vector. Ninety-six hours later 10^6 drug resistant cells were transplanted into CD45.2+ irradiated congenic recipients. To investigate the consequences of FOXC1 expres...
ORGANISM(S): Mus musculus 
2015-09-17 | E-GEOD-66253 | biostudies-arrayexpress
GenomicsFoxc1 ChIP-seq in Gli2-mGFP NIH3T3 cells stably expressing Foxc1 ORF
Foxc1 ChIP-seq in Gli2-mGFP NIH3T3 cells stably expressing Foxc1 ORF
PRJNA1266625 | ENA
ProteomicsEnhancer recruitment of transcription repressors RUNX1 and TLE3 by mis-expressed FOXC1 blocks differentiation in acute myeloid leukemia
Despite absent expression in normal hematopoiesis, the Forkhead factor FOXC1, a critical mesenchymal differentiation regulator, is highly expressed in ~30% of HOXAhigh AML to confer blocked monocyte/macrophage differentiation. Through integrated proteomics and bioinformatics, we discovered that F...
ORGANISM(S): Homo sapiens (Human) 
2021-08-08 | PXD027740 | Pride
Runx1 Groucho Foxc1 Tle3 Acute myeloid leukemia 
GenomicsFoxc1 IIBA ChIP-seq
Foxc1 IIBA ChIP-seq
PRJEB6641 | ENA
TranscriptomicsFoxc1 reinforces quiescence in hair follicle stem cells
Quiescent stem cells are periodically activated to maintain tissue homeostasis or occasionally called into action upon injury. Molecular mechanisms that constitutively maintain stem cell identity or promote stem cell proliferation and differentiation upon activation have been extensively studied. Ho...
ORGANISM(S): Mus musculus 
2016-02-05 | E-GEOD-67404 | biostudies-arrayexpress
GenomicsFOXC1 in triple negative breast cancer [ChIP-seq]
FOXC1 in triple negative breast cancer [ChIP-seq]
PRJNA882756 | ENA
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