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TranscriptomicsAdipose subtype-selective recruitment of TLE3 in thermogenic gene programs
Transcriptional effectors of white adipocyte-selective gene expression have not been described. TLE3 is a white-selective cofactor that acts reciprocally with the brown-selective cofactor Prdm16 to specify lipid storage and thermogenic gene programs. When expressed at elevated levels in brown fat, T...
ORGANISM(S): Mus musculus 
2013-09-27 | E-GEOD-51223 | biostudies-arrayexpress
ProteomicsEnhancer recruitment of transcription repressors RUNX1 and TLE3 by mis-expressed FOXC1 blocks differentiation in acute myeloid leukemia
Despite absent expression in normal hematopoiesis, the Forkhead factor FOXC1, a critical mesenchymal differentiation regulator, is highly expressed in ~30% of HOXAhigh AML to confer blocked monocyte/macrophage differentiation. Through integrated proteomics and bioinformatics, we discovered that F...
ORGANISM(S): Homo sapiens (Human) 
2021-08-08 | PXD027740 | Pride
Runx1 Groucho Foxc1 Tle3 Acute myeloid leukemia 
GenomicsTLE3 CUT&Tag-Seq to characterize TLE3-binding sites in colonic macrophages
TLE3 CUT&Tag-Seq to characterize TLE3-binding sites in colonic macrophages
PRJNA825591 | ENA
GenomicsTLE3 function in rhabdomyosarcoma tumor xenografts.
TLE3 function in rhabdomyosarcoma tumor xenografts.
PRJNA836779 | ENA
GenomicsMapping dynamic Tle3 distribution during CD8 T cell responses
Mapping dynamic Tle3 distribution during CD8 T cell responses
PRJNA878819 | ENA
GenomicsImpact of Tle3 deficiency on memory T cell transcriptome
Impact of Tle3 deficiency on memory T cell transcriptome
PRJNA878821 | ENA
GenomicsRNA-sequencing of Control and TLE3-deficient Beige Adipocytes
RNA-sequencing of Control and TLE3-deficient Beige Adipocytes
PRJNA480509 | ENA
UnknownTLE3 Sustains Luminal Breast Cancer Lineage Fidelity to Suppress Metastasis.
Not available
S-EPMC10089698 | biostudies-literature
GenomicsImpact of Tle3 deficiency on memory T cell chromatin accessbility landscape
Impact of Tle3 deficiency on memory T cell chromatin accessbility landscape
PRJNA878814 | ENA
UnknownPan-Cancer Analysis of TLE3 Revealed Its Value in Tumor Microenvironment and Prognosis.
Not available
S-EPMC9705091 | biostudies-literature
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