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MetabolomicsTFAM loss induces nuclear actin assembly upon mDia2 malonylation to promote liver cancer metastasis
The mechanisms underlying cancer metastasis remain poorly understood. Here, we report that TFAM deficiency rapidly and stably induced spontaneous lung metastasis in mice with liver cancer. Interestingly, unexpected polymerization of nuclear actin was observed in TFAM-knockdown HCC cells when cytoske...
2022-06-23 | MTBLS4307 | MetaboLights
ProteomicsMass spectrometry detected proteins interacting with DPP4 in C28/I2 cells
To understand the mechanisms responsible for DPP4 in osteoarthritis, we examined the proteins that interact with DPP4 using IP followed by mass spectrometry.
ORGANISM(S): Homo Sapiens 
PXD054366 |
ProteomicsSpatiotemporally-resolved mapping of extracellular proteomes via in vivo-compatible TyroID
Extracellular proteins play pivotal roles in both intracellular signaling and intercellular communications in health and disease. While recent advancements in proximity labeling (PL) methods, such as peroxidase- and photocatalyst-based approaches, have facilitated the resolution of extracellular pro...
ORGANISM(S): Homo Sapiens Mus Musculus Bos Taurus 
2024-11-21 | PXD054796 |
ProteomicsComparative proteomic Analysis of wheat roots
Root is of vital important in acquiring nutrients and water from soils. Uncovering the regulatory mechanism of wheat root growth is of great help for genetic improvement of roots traits. A comparative proteomic analysis was performed. Expressed proteins were identified under CK and LN conditions. Pr...
ORGANISM(S): Triticum Aestivum 
2018-03-19 | PXD008793 |
ProteomicsRNA-Pull down and MS for Snhg3
To screen Snhg3-binding proteins using-RNA Pull down and MS
ORGANISM(S): Mus Musculus 
2023-01-17 | PXD039526 |
ProteomicsIdentification of ANXA1 as A Novel Upstream Negative Regulator of Notch1 Function in AML
Abnormal Notch1 expression has an important role in tumorigenesis. However, upstream control mechanisms for Notch1 are still insufficiently understood. Acute myeloid leukemia (AML) is one of the most common and lethal blood malignancies with limited possibilities for treatment. Thus, new therapeutic...
ORGANISM(S): Homo Sapiens 
PXD056593 |
ProteomicsDDX5-sIL-36R in keratinocytes controls skin inflammation
The DEAD-box (DDX) proteins function in diverse cellular processes including RNA alternative splicing, and are linked to immune-mediated diseases. However, little is known about the roles of DDXs in skin inflammatory diseases. Here, we show that DDX5, one of the founding members of the DDX RNA helic...
ORGANISM(S): Homo Sapiens 
PXD021379 |
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