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TranscriptomicsGW7647 and Rosiglitazone treated human differentiated adipocytes
Objective : This work aimed at characterizing PPARα involvement in metabolism regulation and at comparing PPARα and PPARγ roles in human white adipocytes. Research Design and Methods : Profiling of gene expression alterations was assessed with microarrays and RT-qPCR. Primary cultures of human adipo...
ORGANISM(S): Homo sapiens 
2010-04-11 | E-GEOD-15862 | biostudies-arrayexpress
GenomicsSynergism between PPARα and glucocorticoid receptor signaling promotes self-renewal of BFU-E erythroid progenitors and increases red cell production [ChIP-seq]
ChIP-Seq analyses of GR and PPARa occupancy in mouse E14.5 fetal liver BFU-E cells untreated or treated by DEX with or without GW7647 ChIP-Seq on GR and PPAR alpha in purified 10^7 mouse BFU-E cells purified from E14.5 fetal livers with or without treatment of Dexamethasone and/or GW7647
ORGANISM(S): Mus musculus 
2015-06-08 | E-GEOD-62788 | biostudies-arrayexpress
TranscriptomicsSynergism between PPAR? and glucocorticoid receptor signaling promotes self-renewal of BFU-E erythroid progenitors and increases red cell production [RNA-seq]
Analyses of gene expression by RNA-Seq in mouse E14.5 fetal liver burst-forming unit erythroid (BFU-E) cells untreated or treated by dexamethasone (DEX) with or without PPAR? agonist GW7647. RNA-Seq was performed on enriched populations of mouse BFU-E isolated from E14.5 fetal liver, as well as BFU-...
ORGANISM(S): Mus musculus 
2015-06-08 | E-GEOD-63836 | biostudies-arrayexpress
TranscriptomicsProfiling of promoter occupancy by PPARM-NM-1 in human hepatoma cells via ChIP-chip analysis
The transcription factor Peroxisome Proliferator-Activated Receptor M-NM-1 (PPARM-NM-1) is an important regulator of hepatic lipid metabolism. While PPARM-NM-1 is known to activate transcription of numerous genes, no comprehensive picture of PPARM-NM-1 binding to endogenous genes has yet been report...
ORGANISM(S): Homo sapiens 
2010-11-23 | E-GEOD-25547 | biostudies-arrayexpress
TranscriptomicsGW7647 and Rosiglitazone treated human differentiated adipocytes
Objective : This work aimed at characterizing PPARα involvement in metabolism regulation and at comparing PPARα and PPARγ roles in human white adipocytes. Research Design and Methods : Profiling of gene expression alterations was assessed with microarrays and RT-qPCR. Primary cultures of human adipo...
ORGANISM(S): Homo sapiens 
2010-04-11 | GSE15862 | GEO
TranscriptomicsA map of the PPARα transcription regulatory network for primary human hepatocytes
Nuclear receptor activation in liver leads to coordinated alteration of the expression of multiple gene products with attendant phenotypic changes of hepatocytes. Peroxisome proliferators including endogenous fatty acids, environmental chemicals, and drugs induce a multi-enzyme metabolic response th...
ORGANISM(S): Homo sapiens 
2013-12-18 | E-GEOD-53399 | biostudies-arrayexpress
GenomicsHomo sapiens
GW7647 and Rosiglitazone treated human differentiated adipocytes
PRJNA116963 | ENA
GenomicsResponse of primary hepatocytes and liver to GW7647
Response of primary hepatocytes and liver to GW7647
PRJNA289106 | ENA
GenomicsRattus norvegicus
Response of primary hepatocytes to GW7647
PRJNA289108 | ENA
TranscriptomicsResponse of primary hepatocytes to GW7647
Activation of PPARα pathways by some environmental chemicals causes hepatocyte proliferation and cancer in rodents. While these responses do not seem to occur in humans, the biological basis of these species differences remains uncertain. We systematically evaluated multiple readouts in rat and huma...
ORGANISM(S): Rattus norvegicus 
2017-07-01 | GSE70585 | GEO
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