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ProteomicsMonitor precursor mass shifts of Halobacterium salinarum
Approximately 2x106 CL1-5 and H23 cells were seeded on 10-cm dishes with RPMI-1640 medium containing 10% fetal bovine serum. After the cells covered 80% of the dish, cells were serum-starved for 24 h in RPMI-1640 medium. CL1-5 and H23 cell lysates were harvested, trypsinized and analyzed by using LT...
ORGANISM(S): Homo sapiens (Human) Halobacterium salinarum 
2020-01-14 | PXD000082 | Pride
Cl1-5 lysate Nrc-1 gvd lysate Nrc-1 lysate Ltq-orbitrap xl Ltq-orbitrap discovery H23 lysate Human nsclc cell line Halobacterium salinarum nrc-1 Lc-ms/ms 
ProteomicsProteomic approach for searching of universal, tissue-specific and line-specific markers of extracellular vesicles in lung and colorectal adenocarcinoma cell lines: whole cell lysate vs. extracellular vesicles
The efficiency of anticancer therapy depends heavily on the molecular features of the tumor. Since tumor-derived extracellular vesicles, including exosomes, contain proteins that are characteristic for producer cells and could be detected in biological fluids, they are of great interest for screenin...
ORGANISM(S): Homo sapiens (Human) 
2021-09-09 | PXD020454 | Pride
Extracellular vesicles  exosomes  proteomics  mass-spectrometry  colon cancer  lung cancer  biomarkers 
UnknownRapid and reproducible single-stage phosphopeptide enrichment of complex peptide mixtures: application to general and phosphotyrosine-specific phosphoproteomics experiments.
Not available
S-EPMC3251014 | biostudies-literature
ProteomicsA novel small molecule that induces cytotoxicity in lung cancer cells inhibits disulfide reductases GSR and TXNRD1
Phenotype-based screening can identify unique small molecules that elicit a desired cellular response, but additional approaches are required to characterize their targets and mechanisms of action. Here we show that a compound termed LCS3, which selectively impairs the growth of human lung adenocarc...
ORGANISM(S): Homo sapiens (Human) 
2022-04-04 | PXD030294 | Pride
Lcs3 Thermal proteome profiling 
TranscriptomicsmiRNA profiling of LNCaP cells treated with bortezomib or celastrol against untreated control group
This study is designed for exploring miRNAs affected by proteasome inhibitor treatment. LNCaP cells were treated with 100nM bortezomib or 2.5 uM celastrol for 12 hrs, and was subjected to miRNA profiling assay.
ORGANISM(S): Homo sapiens 
2020-12-30 | E-MTAB-6215 | biostudies-arrayexpress
ProteomicsCeritinib Functional Proteomics
To elucidate the mechanism of action (MoA) of ceritinib’s antiproliferative activity in these cells, we applied a systems approach combining both chemical and phosphoproteomics to gain a global view of ceritinib’s target profile and network-wide phosphorylation changes following ceritinib treatment.
ORGANISM(S): Homo sapiens (Human) 
2018-01-12 | PXD007137 | Pride
Phosphoproteomics Chemical proteomics 
ProteomicsComprehensive proteomic profiling of the differences between Cancer Associated Fibroblasts and KRAS mutated cancer cell lines
Cancer associated fibroblasts (CAFs) are a key component of tumors. We aimed to profile the proteome of cancer cell lines representing three common cancer types (lung, colorectal and pancreatic) and a representative CAF cell line from each tumor type to gain insight into CAF function and identify ne...
ORGANISM(S): Homo sapiens (Human) 
2024-08-22 | PXD054500 | Pride
Cancer associated fibroblasts Kras Cafs 
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