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ProteomicsPhosphorylation of methyltransferase Set2p and demethylase Jhd1p and its association with histone H3K36 methylation and stress response pathways in Saccharomyces cerevisiae
Histone lysine methylation is a key epigenetic modification that regulates eukaryotic transcription. In Saccharomyces cerevisiae, it is controlled by a reduced but evolutionarily conserved suite of methyltransferase (Set1p, Set2p, Dot1p, and Set5p) and demethylase (Jhd1p, Jhd2p, Rph1p, and Gis1p) en...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2022-03-07 | PXD029088 | Pride
Epigenetics Demethylase Signalling Histone methylation Yeast Chromatin Methyltransferase 
TranscriptomicsTranscription profiling of mouse NUP98-NSD1 transformed samples reveals NUP98-NSD1 links H3K36 methylation to Hox-A gene activation and leukaemogenesis. INCOMPLETE DATASET
Nuclear receptor-binding SET domain protein 1 (NSD1) prototype is a family of mammalian histone methyltransferases (NSD1, NSD2/MMSET/WHSC1, NSD3/WHSC1L1) that are essential in development and are mutated in human acute myeloid leukemia (AML), overgrowth syndromes, multiple myeloma and lung cancers. ...
ORGANISM(S): Mus musculus 
2008-06-11 | E-GEOD-10071 | biostudies-arrayexpress
TranscriptomicsHistone H3K36 trimethylation is essential for multiple silencing mechanisms in fission yeast.
In budding yeast, Set2 catalyzes di- and trimethylation of H3K36 (H3K36me2 and H3K36me3) via an interaction between its SRI domain and C-terminal repeats of RNA polymerase II (Pol2) phosphorylated at Ser2 and Ser5 (CTD-S2,5-P). H3K36me2 recruits the Rpd3S histone deacetylase complex to repress crypt...
ORGANISM(S): Schizosaccharomyces pombe 
2016-02-04 | E-GEOD-66821 | biostudies-arrayexpress
UnknownH3K36 methylation antagonizes PRC2-mediated H3K27 methylation.
Not available
S-EPMC3048685 | biostudies-literature
TranscriptomicsH3K36 mutations promote sarcomagenesis through genome-wide remodeling of H3K36 and H3K27 methylation
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Drosophila melanogaster 
2016-05-13 | E-GEOD-69291 | biostudies-arrayexpress
TranscriptomicsH3K36 mutations promote sarcomagenesis through genome-wide remodeling of H3K36 and H3K27 methylation [Ring1a-1b_RNASeq]
The goal of this study is to understand the genome-wide alterations in chromatin landscapy induced by a histone mutation (H3.3 K36M) derived from chondroblastomas Examination of the transcriptome changes of Ring1a and Ring1b knockdown in mouse mesenchymal progenitor cells
ORGANISM(S): Mus musculus 
2016-05-13 | E-GEOD-75854 | biostudies-arrayexpress
GenomicsH3K36 mutations promote sarcomagenesis through genome-wide remodeling of H3K36 and H3K27 methylation [Cbx2_ChIP]
The goal of this study is to understand the genome-wide alterations in chromatin landscape induced by a histone mutation (H3.3K36M) derived from chondroblastomas Examination of genome-wide Cbx2 distribution in cells expressing H3.3WT and H3.3K36M.
ORGANISM(S): Mus musculus 
2016-05-13 | E-GEOD-75856 | biostudies-arrayexpress
TranscriptomicsH3K36 mutations promote sarcomagenesis through genome-wide remodeling of H3K36 and H3K27 methylation [RNA_Chondroblastoma_H3K36M_H3WT]
The goal of this study is to understand the genome-wide alterations in chromatin landscapy induced by a histone mutation (H3.3 K36M) derived from chondroblastomas Examination of H3K36M mutations to H3WT Chondroblastomas.
ORGANISM(S): Homo sapiens 
2016-05-13 | E-GEOD-75853 | biostudies-arrayexpress
GenomicsH3K36 mutations promote sarcomagenesis through genome-wide remodeling of H3K36 and H3K27 methylation [Ring1b_ChIP]
The goal of this study is to understand the genome-wide alterations in chromatin landscape induced by a histone mutation (H3.3K36M) derived from chondroblastomas Examination of genome-wide Ring1b distribution in cells expressing H3.3WT and H3.3K36M.
ORGANISM(S): Mus musculus 
2016-05-13 | E-GEOD-69286 | biostudies-arrayexpress
GenomicsGlobal analysis of H3K36 methylation in the MM genome
Global analysis of H3K36 methylation in the MM genome
PRJNA1192265 | ENA
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