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TranscriptomicsExpression data of NCI-H441 cells stably expressing hsa-mir-365-2 vs empty vector
Hsa-mir-365-2 is one of the two precursors that give rise to miR-365. We discovered that miR-365 directly regulates a lung cancer and developmental gene termed thyroid transcription factor 1 (TTF-1 or NKX2-1). Hsa-mir-365-2 was transfected into NCI-H441 cells via retrovirus-mediated gene transfer. A...
ORGANISM(S): Homo sapiens 
2011-11-15 | E-GEOD-33672 | biostudies-arrayexpress
TranscriptomicsCLEFMA selectively induces necrotic cell death of H441 lung adenocarcinoma cells via oxidative stress
Despite the growing understanding about the molecular basis of oncogenesis, prevention and cure of cancer remains an unsurpassed challenge. Chemotherapeutic drugs are the mainstay in managing patients diagnosed with any form of cancer. The emergent chemo-resistance, morbid toxicities and overall ine...
ORGANISM(S): Homo sapiens 
2010-12-18 | E-GEOD-23420 | biostudies-arrayexpress
ProteomicsAnalysis of the cellular effect of 1α,25-dihydroxyvitamin D3 on lung NCI-H441 cells
Low serum levels or deficiency of 1α,25-dihydroxyvitamin D3 (VD3) are associated with a higher mortality in trauma patients with sepsis or acute respiratory distress syndrome, although the molecular mechanisms behind this observation are not yet understood. VD3 is known to stimulate lung maturity, a...
ORGANISM(S): Homo sapiens (Human) 
2023-05-10 | PXD040622 | Pride
Vitamin d3 Nci-h441 cells Alveolar-capillary barrier Lung Isobaric labelling Biomarker 
GenomicsSmad3, Smad4 and TTF-1/NKX2-1 binding sites in H441/A549 lung cancer cell lines
We evaluated the role of TTF-1/NKX2-1 on Smad3 and Smad4 binding in lung cancer cell lines. Smad3 binding sites in A549 cells and Smad3, Smad4, and TTF-1/NKX2-1 binding sites in H441 cells were determined by ChIP-seq.
ORGANISM(S): Homo sapiens 
2014-07-27 | E-GEOD-51509 | biostudies-arrayexpress
GenomicsIdentification of genome-wide FOXA2-binding sites in H441 human lung adenocarcinoma cells
Identification of genome-wide FOXA2-binding sites in H441 human lung adenocarcinoma cells
PRJNA863630 | ENA
GenomicsDifferential mRNA expression analysis of H441 cells after BSGL and RSGL treatment
Differential mRNA expression analysis of H441 cells after BSGL and RSGL treatment
PRJNA918984 | ENA
ProteomicsDIA-PASEF Proteomic Analysis of Metabolic Responses to Amino Acid Supplementation in H441 Cells
This dataset contains untargeted proteomic measurements from H441 epithelial cells cultured under physiologic metabolic conditions. Cells were conditioned in human plasma–like medium (HPLM) and treated with or without an amino acid supplement. Proteomic profiling was performed to quantify global pr...
ORGANISM(S): Homo sapiens (Human) 
2026-03-11 | PXD072867 | Pride
Human Timstof ultra 2 Lcms 
GenomicsExpression of genes affected by ectopic expression of FOXA2 in H441 human lung adenocarcinoma cells
Expression of genes affected by ectopic expression of FOXA2 in H441 human lung adenocarcinoma cells
PRJNA863629 | ENA
TranscriptomicsExpression data of human lung adenocarcinoma cell line H441 treated with TTF-1/NKX2-1 siRNA and TGF-beta
We determined and analyzed the effect of TTF-1/NKX2-1 on Smad3/Smad4 binding sites by ChIP-sequencing. We used expression microarrays to evaluate the effect of TTF-1/NKX2-1 siRNA on TGF-beta-induced gene expressions. H441 cells were transfected with siRNAs and treated with TGF-beta for RNA extractio...
ORGANISM(S): Homo sapiens 
2014-07-27 | E-GEOD-49675 | biostudies-arrayexpress
UnknownExpression of surfactant protein B is dependent on cell density in H441 lung epithelial cells.
Not available
S-EPMC5599067 | biostudies-literature
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