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GenomicsKMT9 writes the H4K12me1 histone mark and controls metabolism and proliferation of castration-resistant prostate cancer cells [ChIP-seq]
KMT9 is formed by the assembly of KMT9a and KMT9b and writes the H4K12me1 mark. The objectives of this study is to identify KMT9a, KMT9b, and H4K12me1 locations by ChIP-seq in the androgen-independent PC-3M prostate cancer cells and to show that upon KMT9a knockdown the levels of H4K12me1 mark decre...
ORGANISM(S): Homo sapiens 
2019-06-26 | GSE117534 | GEO
ProteomicsKMT9 writes the histone mark H4K12me1 and controls metabolism and proliferation of castration-resistant prostate cancer cells
Posttranslational modifications of histones such as methylation regulate chromatin structure and gene expression. Methylation of histone lysine residues is generally performed by SET domain methyltransferases. Here, we identify the heterodimeric C21orf127/TRMT112 complex as a specific histone methyl...
ORGANISM(S): Homo sapiens (Human) 
2019-03-11 | PXD008965 | Pride
Kmt9 Lysine methylation H4k12me1 Prostate cancer Methyl-silac Chromatin Methyltransferase Trmt112 
GenomicsKMT9 writes the H4K12me1 histone mark and controls metabolism and proliferation of castration-resistant prostate cancer cells [ChIP-seq]
KMT9 writes the H4K12me1 histone mark and controls metabolism and proliferation of castration-resistant prostate cancer cells [ChIP-seq]
PRJNA482409 | ENA
GenomicsKMT9a writes the H4K12me1 histone mark and controls metabolism and proliferation of castration-resistant prostate cancer cells
KMT9a writes the H4K12me1 histone mark and controls metabolism and proliferation of castration-resistant prostate cancer cells
PRJNA482404 | ENA
GenomicsKMT9a writes the H4K12me1 histone mark and controls metabolism and proliferation of castration-resistant prostate cancer cells
This SuperSeries is composed of the SubSeries listed below. Posttranslational modifications of histones such as methylation regulate chromatin structure and gene expression. Methylation of histone lysine residues is generally performed by SET domain methyltransferases. Here, we identify the heterodi...
ORGANISM(S): Homo sapiens 
2019-06-26 | GSE117536 | GEO
GenomicsKMT9a writes the H4K12me1 histone mark and controls metabolism and proliferation of castration-resistant prostate cancer cells [RNA-seq]
KMT9a writes the H4K12me1 histone mark and controls metabolism and proliferation of castration-resistant prostate cancer cells [RNA-seq]
PRJNA482410 | ENA
UnknownDistinct specificities of the HEMK2 protein methyltransferase in methylation of glutamine and lysine residues.
Not available
S-EPMC10804810 | biostudies-literature
GenomicsKMT9 writes the H4K12me1 histone mark and controls metabolism and proliferation of castration-resistant prostate cancer cells [ChIP-Seq 2]
KMT9 writes the H4K12me1 histone mark and controls metabolism and proliferation of castration-resistant prostate cancer cells [ChIP-Seq 2]
PRJNA517820 | ENA
UnknownStructure-Guided Design of a KMT9 Inhibitor Prodrug with Cellular Activity.
Not available
S-EPMC12257510 | biostudies-literature
TranscriptomicsKMT9a writes the H4K12me1 histone mark and controls metabolism and proliferation of castration-resistant prostate cancer cells [RNA-seq]
The aim of the RNA-seq was to identify the KMT9 transcriptome in PC-3M cells. The MCF10A breast epithelial cells that do not express KMT9a were used to show that the siRNA against KMT9 show no off-target effects.
ORGANISM(S): Homo sapiens 
2019-06-26 | GSE117535 | GEO
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