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TranscriptomicsTranscription profiling of mouse 3T3-L1 adipocyte differentiation time series-3T3-L1 adipocyte differentiation timeseries
3T3-L1 adipocyte differentiation time series-3T3-L1 adipocyte differentiation timeseries. Hackl H*, Burkard T*, Sturn A, Rubio R, Schleiffer A, Tian S, Quackenbush J, Eisenhaber F, Trajanoski Z. Molecular processes during fat cell development revealed by gene expression profiling and functional a...
ORGANISM(S): Mus musculus 
2005-01-01 | E-MARS-2 | biostudies-arrayexpress
TranscriptomicsDifferential gene expression in Aspergillus fumigatus induced by human platelets in vitro
Differentially expressed genes in Aspergillus fumigatus following exposure to human platelets in a timeseries experiment (15min, 30min, 1h, 3h) compared to untreated fungi as reference using customized Geniom (R) Biochips (febit) comprising 9500 genes (14051 features) were studied in order to gain a...
ORGANISM(S): Aspergillus fumigatus Af293 
2015-01-22 | E-MTAB-3024 | biostudies-arrayexpress
TranscriptomicsEffect of fetal HDL on gene expression in human placental endothelial cells
The aim of this study was to identify HDL and apoE-regulated genes in human placental endothelial cells (HPEC), which are exposed to fetal HDL. HPECs extracted from 5 human placentas were cultivated and treated for 16 h with 15ug/ml fetal HDL, 15ug/ml reconstituted HDL (rHDL), or endothelial basal m...
ORGANISM(S): Homo sapiens 
2011-09-01 | E-MEXP-3299 | biostudies-arrayexpress
TranscriptomicsEffect of Nur77 on gene expression in white adipose tissue of fasted mice.
The aim was to study the effects of Nur77 on the white adipose tissue transcriptome after fasting. For this purpose we performed gene expression profiling of white adipose tissue from Nur77-/- mice and wildtype (Nur77+/+) littermates submitted to prolonged fasting using microarray analysis on >27k e...
ORGANISM(S): Mus musculus 
2012-11-09 | E-MEXP-3771 | biostudies-arrayexpress
TranscriptomicsGene expression changes in U937 cells in response to ectopic expression of EVI1 and/or etoposide treatment
Overexpression of ecotropic viral integration site 1 (EVI1) is associated with aggressive disease in acute myeloid leukemia (AML). Despite of its clinical importance, little is known about the mechanism through which EVI1 confers resistance to antileukemic drugs. Here, we show that a human myeloid c...
ORGANISM(S): Homo sapiens 
2015-03-10 | E-GEOD-66660 | biostudies-arrayexpress
TranscriptomicsA gene expression profile associated with relapse of cytogenetically normal acute myeloid leukemia is enriched for leukemia stem cell genes
Relapse, associated with therapy resistance, is a major clinical problem in acute myeloid leukemia (AML), yet little is known about the underlying molecular mechanisms. Using genome wide gene expression profiling on 11 paired samples from diagnosis and relapse, we show that the expression of a subst...
ORGANISM(S): Homo sapiens 
2015-03-05 | E-GEOD-66525 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of dendritic cells from three different human donors to characterize the impact of differential HIV opsonization on dendritic cell modulation
The aim of this study was to characterize the impact of differential HIV opsonization on DC modulation. DCs are the most potent antigen-presenting cells and among the first cells HIV is attaching to. HIV spontaneously activates the complement system even in the absence of specific antibodies and is ...
ORGANISM(S): Homo sapiens 
2015-03-31 | E-MEXP-3706 | biostudies-arrayexpress
TranscriptomicsGene expression analysis in proximal and distal colons of Lcn2-/- IL10-/- double knock-out mice.
Lcn2 is involved in host defense against pathogens, but the function in intestinal mucosal immunity and inflammation remains largely unknown. Genetic ablation of Lcn2 results in early-onset colitis and spontaneous emergence of right-sided colonic tumors in the setting of IL-10 deficiency (Lcn2-/-;IL...
ORGANISM(S): Mus musculus 
2016-03-30 | E-MTAB-4583 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of five tissues from HSL knock-out versus wild type mice
Gene expression profiling in 5 tissues (WAT, BAT, CM, LIV, SM) from HSL-/- mice versus wildtype (HSL+/+) mice.
ORGANISM(S): Mus musculus 
2008-06-11 | E-MARS-9 | biostudies-arrayexpress
TranscriptomicsmiRNA expression in AML and healthy controls
Acute myeloid leukemia (AML) is a hematopoietic malignancy with a dismal outcome in the majority of cases. A detailed understanding of the genetic alterations and gene expression changes that contribute to its pathogenesis is important to improve prognostication, disease monitoring, and therapy. The...
ORGANISM(S): Homo sapiens 
2013-08-09 | E-GEOD-49665 | biostudies-arrayexpress
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