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ProteomicsProteome analysis of microvessels from CADASIL patients
CADASIL, the most frequent and intensely studied monogenic SVD, is characterized by a severe pathology in the cerebral vasculature including the mutation-induced aggregation of the Notch3 extracellular domain (Notch3ECD) and the formation of protein deposits of insufficiently determined composition ...
ORGANISM(S): Homo sapiens (Human) 
2018-08-03 | PXD009393 | Pride
Small vessel disease Cadasil Human Microvessels 
ProteomicsProteome analysis of brain microvessels from htra1 KO mice
CARASIL (cerebral autosomal recessive arteriopathy with subcortical infarcts and leukoencephalopathyis) a small-vessel disease caused by loss of function mutaions of htrA1, which cleaves several extracellular matrix proteins. Here, we isolated microvessels from htra1 KO and wild type control mice to...
ORGANISM(S): Mus musculus (Mouse) 
2018-08-03 | PXD009411 | Pride
Small vessel disease Microvessel Carasil 
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