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ProteomicsProteomic analysis of chemical and genetic EZH2 inhibition in diffuse intrinsic pontine glioma cell lines
Diffuse Intrinsic Pontine Glioma (DIPG) is a rare and highly aggressive pediatric tumor. The average survival time after diagnosis is less than one year. Currently, there are no effective treatments. Characteristic of DIPG is a mutation in histone H3 which leads to a substitution of Lysine 27 to Met...
ORGANISM(S): Homo sapiens (Human) 
2022-04-01 | PXD017525 | Pride
Ezh2 inhibition Quantitative proteome Gsk126 Diffuse intrinsic pontine glioma Ezh2 knock down 
ProteomicsProteomic response of diffuse midline glioma to HDAC inhibition reveals adjuvant anti-EBP50 therapy as novel therapeutic concept.
Diffuse midline glioma (DMG) is an aggressive pediatric tumor localized in the brainstem. The median survival after diagnosis is less than one year. Surgical resection is not possible due to the critical localization of the tumor and radiation therapy alone or in combination with chemotherapy show o...
ORGANISM(S): Homo sapiens (Human) 
2021-06-10 | PXD009666 | Pride
Label-free quantitative proteome analysis. Ebp50 Ezrin-radixin-moesin binding protein 50 Diffuse midline glioma Dmg Hdac inhibition 
TranscriptomicsLong noncoding RNA expression during human B-cell development
Long noncoding RNAs (lncRNAs) have emerged as important regulators of diverse cellular processes, but their roles in the developing immune system are poorly understood. In this study, we analysed lncRNA expression during human B-cell development by array-based expression profiling of eleven distinct...
ORGANISM(S): Homo sapiens 
2016-02-09 | E-GEOD-69033 | biostudies-arrayexpress
UnknownFunctional impairments for outcomes in a randomized trial of unruptured brain AVMs.
Not available
S-EPMC5631171 | biostudies-literature
TranscriptomicsGene expression profiles of normal B-cell subsets from sternal bone marrow
Mononuclear cells were isolated from the sternal bone marrow and prepared for multiparametric flow cytometry using an optimized and validated protocol. B-cell subsets of PreBI, PreBII, Immature, Naive, Memory and Plasma cells were isolated and a al of 38 gene expression profiles were generated using...
ORGANISM(S): Homo sapiens 
2016-02-09 | E-GEOD-68878 | biostudies-arrayexpress
UnknownIntegrated Genomic Analysis of the Ubiquitin Pathway across Cancer Types.
Not available
S-EPMC5916807 | biostudies-literature
UnknownDifferent factors limit early- and late-season windows of opportunity for monarch development.
Not available
S-EPMC9273743 | biostudies-literature
UnknownAn Integrated TCGA Pan-Cancer Clinical Data Resource to Drive High-Quality Survival Outcome Analytics.
Not available
S-EPMC6066282 | biostudies-literature
UnknownGenomic and Molecular Landscape of DNA Damage Repair Deficiency across The Cancer Genome Atlas.
Not available
S-EPMC5961503 | biostudies-literature
UnknownMedical management with or without interventional therapy for unruptured brain arteriovenous malformations (ARUBA): a multicentre, non-blinded, randomised trial.
Not available
S-EPMC4119885 | biostudies-literature
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