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GenomicsNfatc1 Orchestrates Aging in Hair Follicle Stem Cells
Mouse hair follicles undergo synchronized cycles. Cyclical regeneration and hair growth is fueled by hair follicle stem cells (HFSCs). We used ChIP-seq to unfold genome-wide chromatin landscapes of Nfatc1 and dissect the biological relevence of its upstream BMP signaling in HFSC aging. Telogen quies...
ORGANISM(S): Mus musculus 
2013-11-14 | E-GEOD-52328 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse hair follicle stem cell
Mouse keratinocytes were isolated from K15-EGFP transgenic mice for FACS sorting. RNA samples from EGFP-high and alpha-6 integrin positive cells (hair follicle stem cells) and from EGFP negative and alpha-6 integrin positive cells were used for Microarray analysis.
ORGANISM(S): Mus musculus 
2007-10-06 | E-GEOD-1096 | biostudies-arrayexpress
TranscriptomicsExpression profiling of mouse dorsal skin during hair follicle cycling
Hair follicles undergo recurrent cycling of controlled growth (anagen), regression (catagen), and relative quiescence (telogen) with a defined periodicity. Taking a genomics approach to study gene expression during synchronized mouse hair follicle cycling, we discovered that, in addition to circadia...
ORGANISM(S): Mus musculus 
2009-07-17 | E-GEOD-11186 | biostudies-arrayexpress
TranscriptomicsExpression profiling of Bmal mutant dorsal skin at telogen of hair follicle cycling
Hair follicles undergo recurrent cycling of controlled growth (anagen), regression (catagen), and relative quiescence (telogen) with a defined periodicity. Taking a genomics approach to study gene expression during synchronized mouse hair follicle cycling, we discovered that, in addition to circadia...
ORGANISM(S): Mus musculus 
2010-04-08 | E-GEOD-14006 | biostudies-arrayexpress
ProteomicsImpact of SDF-1 and AMD3100 on Hair Follicle Dynamics in a Chronic Stress Model
Chronic stress is a common cause of hair loss, involving inflammatory responses and changes in cellular signaling pathways. This study explores the mechanism of action of the SDF-1/CXCR4 signaling axis in chronic stress-induced hair loss. The research indicates that SDF-1 promotes hair follicle grow...
ORGANISM(S): Mus Musculus 
PXD056932 |
TranscriptomicsRNAseq of organ-cultured human hair follicles exposed to MEKi (Cobimetinib)
EGFR/MEK inhibitor therapy induces a distinct inflammatory hair follicle response that includes a collapse of hair follicle immune privilege and differential modulation of IL-33 and IL-37 expression. Our findings suggest that successful future management of EGFRi/MEKi-induced folliculitis requires r...
ORGANISM(S): Homo sapiens 
2024-07-19 | E-MTAB-13454 | biostudies-arrayexpress
TranscriptomicsLgr6 Marks Stem Cells in the Hair Follicle that Generate all Cell Lineages of the Skin
Mammalian epidermis consists of three self-renewing compartments: the hair follicle, sebaceous gland and interfollicular epidermis. We generated knock-in alleles of murine Lgr6, a close relative to the Lgr5 stem cell gene. Lgr6 was expressed in the earliest embryonic hair placodes. In adult hair fol...
ORGANISM(S): Mus musculus 
2010-03-25 | E-GEOD-20269 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human hair follicles from men and women
Investigation of Gene Expression Profiling in Unstaged Head Hair Follicles Plucked from Men and Women Experiment Overall Design: Total RNA was extracted from 1-3 unstaged follicles plucked from the scalp of each of 36 adult human volunteers. The average quantifiable yield of RNA per follicle was 11...
ORGANISM(S): Homo sapiens 
2007-12-11 | E-GEOD-3058 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of different types of cells in murine hair follicle to study cell type-specific gene expression.
Hair follicle matrix, outer root sheath, dermal papilla cells and melanocytes and a dermal fraction enriched in fibroblasts were FACS isolated from 4d backskins. Targets from two biological replicates of each were generated and the expression profiles were determined using Affymetrix Mouse Genechip...
ORGANISM(S): Mus musculus 
2007-09-07 | E-GEOD-3142 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Lgr6+ keratinocyte populations in the epidermis and hair follicle
RNA sequencing was performed on sorted populations of Lgr6-positive and Lgr6-negative keratinocytes from the interfollicular epidermis and the hair follicle/sebaceous gland, in order to determine the compartment-specific expression signatures of Lgr6+ progenitor cells.
ORGANISM(S): Mus musculus 
2015-10-22 | E-MTAB-3533 | biostudies-arrayexpress
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