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ProteomicsProteomic Genotyping: Using Mass Spectrometry to Infer SNP Genotypes in Pigmented and Non-Pigmented Hair
Proteomic genotyping is the use of genetically variant peptides (GVPs), detected in a forensic protein sample, to infer the genotype of corresponding non-synonymous SNP alleles in the donor’s genome. This process does not depend on the presence of accessible or useable DNA in a sample. This makes pr...
ORGANISM(S): Homo sapiens (Human) 
2020-05-27 | PXD016156 | Pride
Proteomic genotyping Hair Hair pigmentation Melanosomes Genetically variant peptides 
ProteomicsProfiling Protein Expression Levels and Genetically Variant Peptides in Human Hair From Different Body Sites
Proteins of the human hair shaft contain a wealth of information about the coding regions of the person’s genome from whom the hair is derived. Commonly found at crime scenes, hair shafts may thus provide useful forensic evidence if the information they contain can be exploited. Present experiments ...
ORGANISM(S): Homo sapiens (Human) 
2019-04-04 | PXD011732 | Pride
Protein profiling Hair shafts Genetically variant peptides Human identification 
ProteomicsStability of hair proteomes and proteomic genotyping with age and time
Hair, a skin appendage, is a frequently procured biological specimen from crime scenes and has been used in forensic investigations for over a century. Proteomic analysis and identification of genetically variant peptides (GVPs) in hair samples for identification purposes is a recent but an efficien...
ORGANISM(S): Homo sapiens (Human) 
2020-06-10 | PXD016169 | Pride
Hair Genetically variant peptides Hair protein profiles Forensic proteomics Proteomic genotyping 
ProteomicsImpact of SDF-1 and AMD3100 on Hair Follicle Dynamics in a Chronic Stress Model
Chronic stress is a common cause of hair loss, involving inflammatory responses and changes in cellular signaling pathways. This study explores the mechanism of action of the SDF-1/CXCR4 signaling axis in chronic stress-induced hair loss. The research indicates that SDF-1 promotes hair follicle grow...
ORGANISM(S): Mus Musculus 
2024-10-18 | PXD056932 |
TranscriptomicsTranscription profiling of Gata3 conditional knock out mice to investigate epidermis and hair follicle differentiation
Transcriptome analysis on Gata3 conditional knock out murine hair follicles. Background. The transcription factor Gata3 is critically involved in epidermis and hair follicle differentiation. Yet, little is known about how Gata3 co-ordinates stem cell lineage determination in skin, which processes ar...
ORGANISM(S): Mus musculus 
2007-01-01 | E-MEXP-634 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse wildtype and Foxn1::dnFGFR2-IIIb transgenic hair follicles
rationale: comparison of gene expression profiles in wildtype and Foxn1::dnFGFR2-IIIb transgenic hair follicles; identification of targets that mediate the effects seen in transgenic hair follicles; results: as already suggested by the phenotype, the molecular abnormalities appear to be restricted t...
ORGANISM(S): Mus musculus 
2008-06-12 | E-GEOD-2463 | biostudies-arrayexpress
MetabolomicsOVCAR-3 spheroid-derived cells display distinct metabolic profiles
Recently, multicellular spheroids were isolated from a well-established epithelial ovarian cancer cell line, OVCAR-3, and were propagated in vitro. These spheroid derived cells displayed numerous hallmarks of cancer stem cells, which are chemo and radioresistant cells thought to be a significant cau...
2015-01-08 | MTBLS152 | MetaboLights
ProteomicsInner ear hair cell proteome
The mammalian inner ear subserves auditory and vestibular sensations via highly specialized cells and proteins. We show that sensory hair cells (HCs) employ hundreds of uniquely or highly expressed proteins for processes involved in transducing mechanical inputs, stimulating sensory neurons, and mai...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2016-05-23 | MSV000079756 | MassIVE
TranscriptomicsTranscription profiling of different types of cells in murine hair follicle to study cell type-specific gene expression.
Hair follicle matrix, outer root sheath, dermal papilla cells and melanocytes and a dermal fraction enriched in fibroblasts were FACS isolated from 4d backskins. Targets from two biological replicates of each were generated and the expression profiles were determined using Affymetrix Mouse Genechip...
ORGANISM(S): Mus musculus 
2007-09-07 | E-GEOD-3142 | biostudies-arrayexpress
TranscriptomicsThe Transcriptome of Utricle Hair Cell Regeneration in the Avian Inner Ear
A comprehensive transcriptome profile of chicken utricle hair cell across a 7 days regenerative time course. Compare gene expression changes in chicken utricle treated with streptomycin to the control. A total of 60 samples were collected from 11 different time points. Each time point contains at le...
ORGANISM(S): Gallus gallus 
2014-04-29 | E-GEOD-57134 | biostudies-arrayexpress
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