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MetabolomicsRoot hair developmental regulators orchestrate drought induced microbiome changes and affect the interactions with stress alleviating Rhizobiaceae

Drought is one of the most severe abiotic stresses. However, there is a lack of genetic evidence regarding whether and how plants coordinate the dynamic assembly of the microbiome in response to drought. Through the use of mutants with enhanced or reduced root hair densities (rsl2 rsl4, hairless ...

2024-10-28 | MTBLS11360 | MetaboLights
TranscriptomicsRNAseq of organ-cultured human hair follicles exposed to MEKi (Cobimetinib)
EGFR/MEK inhibitor therapy induces a distinct inflammatory hair follicle response that includes a collapse of hair follicle immune privilege and differential modulation of IL-33 and IL-37 expression. Our findings suggest that successful future management of EGFRi/MEKi-induced folliculitis requires r...
ORGANISM(S): Homo sapiens 
2024-07-19 | E-MTAB-13454 | biostudies-arrayexpress
ProteomicsProteomic Genotyping: Using Mass Spectrometry to Infer SNP Genotypes in Pigmented and Non-Pigmented Hair
Proteomic genotyping is the use of genetically variant peptides (GVPs), detected in a forensic protein sample, to infer the genotype of corresponding non-synonymous SNP alleles in the donor’s genome. This process does not depend on the presence of accessible or useable DNA in a sample. This makes pr...
ORGANISM(S): Homo sapiens (Human) 
2020-05-27 | PXD016156 | Pride
Proteomic genotyping Hair Hair pigmentation Melanosomes Genetically variant peptides 
TranscriptomicsTranscription profiling of human hair follicles from men and women
Investigation of Gene Expression Profiling in Unstaged Head Hair Follicles Plucked from Men and Women Experiment Overall Design: Total RNA was extracted from 1-3 unstaged follicles plucked from the scalp of each of 36 adult human volunteers. The average quantifiable yield of RNA per follicle was 11...
ORGANISM(S): Homo sapiens 
2007-12-11 | E-GEOD-3058 | biostudies-arrayexpress
ProteomicsReprocessed: Chick utricle hair bundles and utricular epithelium—Orbitrap
This is a reanalysis of PXD000104. Purified hair bundles and utricular epithelium from E19-E20 chick inner ears were analyzed by LC-MS/MS to determine the abundant and enriched proteins of the hair bundle. This dataset used a Thermo Orbitrap Elite mass spectrometer for protein detection.
ORGANISM(S): Gallus gallus (Chicken) 
2015-11-17 | PXD002445 | Pride
Vestibular Hair cells Stereocilia Utricle 
ProteomicsHuman hair shaft LC-MS/MS - Studies on the Proteome of Human Hair - Identification of Histones and Deamidated Keratins
The aim of this work was to define the hair proteome after extractions with both detergent and detergent-free buffers using highly sensitive proteomics technologies based on mass spectrometry.
ORGANISM(S): Homo sapiens (Human) 
2018-01-30 | PXD007224 | Pride
Human scalp hair shaft 
ProteomicsMouse wild-type and Anxa5-null utricles and hair bundles
The phospholipid- and Ca2+-binding protein annexin A5 (ANXA5) is the most abundant membrane-associated protein of ~P23 mouse vestibular hair bundles, present at ~15,000 copies per stereocilium, which is ~2% of the total protein there. Although seven other annexin genes are expressed in mouse utricle...
ORGANISM(S): Mus musculus (Mouse) 
2016-06-09 | PXD003005 | Pride
Hair cells Annexins Vestibular Stereocilia 
TranscriptomicsEffects of a Closed Space Environment on Gene Expression in Hair Follicles of Astronauts in the International Space Station
In recent times, long-term stay has become a common occurrence in the International Space Station (ISS). However, adaptation to the space environment can sometimes pose physiological problems to the astronauts after their return. Therefore, it is important to develop healthcare technologies for astr...
ORGANISM(S): Homo sapiens 
2016-03-31 | E-GEOD-74708 | biostudies-arrayexpress
GenomicsNfatc1 Orchestrates Aging in Hair Follicle Stem Cells
Mouse hair follicles undergo synchronized cycles. Cyclical regeneration and hair growth is fueled by hair follicle stem cells (HFSCs). We used ChIP-seq to unfold genome-wide chromatin landscapes of Nfatc1 and dissect the biological relevence of its upstream BMP signaling in HFSC aging. Telogen quies...
ORGANISM(S): Mus musculus 
2013-11-14 | E-GEOD-52328 | biostudies-arrayexpress
ProteomicsIDENTIFICATION AND CHARACTERISATION OF TAXONOMICALLY INFORMATIVE PEPTIDES BY HIGH RESOLUTION MASS SPECTROMETRY FOR SOURCE IDENTIFICATION OF TRACE HAIR
In this study a proteomics workflow was developed for the discovery and characterization of taxonomically diagnostic hair peptides. Taxa were selected with a focus on relevance to crime scene investigation. A panel of 226 taxonomically informative peptides were identified and characterized, 209 whic...
ORGANISM(S): Bos taurus (Bovine) Sus scrofa (Pig) Camelus dromedarius (Dromedary) (Arabian camel) Vicugna pacos Mus musculus (Mouse) Homo sapiens (Human) Canis lupus Oryctolagus cuniculus (Rabbit) Felis catus (Cat) (Felis silvestris catus) Cavia porcellus (Guinea pig) Rattus norvegicus (Rat) Equus caballus (Horse) 
2026-05-13 | PXD065721 | Pride
Taxonomically informative biomarkers Hair proteins Forensic proteomics Trace evidience 
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