Sort   by:  
 Page size 
ProteomicsRapid and reversible knockdown of endogenously tagged endosomal proteins via an optimized HaloPROTAC degrader
Combining pharmacologic and genetic tools to induce post-translational protein knockdown is an emerging approach to probe biology and validate potential drug targets. A powerful strategy involves expression of a protein of interest fused to an exogenous tag, allowing tag-directed chemical degraders ...
ORGANISM(S): Homo sapiens (Human) 
2019-11-13 | PXD012828 | Pride
Haloprotac Vps34 Degradation 
UnknownRapid and Reversible Knockdown of Endogenously Tagged Endosomal Proteins via an Optimized HaloPROTAC Degrader.
Not available
S-EPMC6528276 | biostudies-literature
UnknownInducible Degradation of Target Proteins through a Tractable Affinity-Directed Protein Missile System.
Not available
S-EPMC7505680 | biostudies-literature
UnknownSystematic comparison and base-editing-mediated directed protein evolution and functional screening yield superior auxin-inducible degron technology.
Not available
S-EPMC12274581 | biostudies-literature
UnknownComparative analysis and directed protein evolution yield an improved degron technology with minimal basal degradation, rapid inducible depletion, and faster recovery of target proteins.
Not available
S-EPMC11601833 | biostudies-literature
TranscriptomicsSystematic comparison and base-editing-mediated directed protein evolution and functional screening yield superior auxin-inducible degron technology
Biological mechanisms are inherently dynamic, requiring precise and rapid manipulations for effective characterization. Traditional genetic manipulations operate on long timescales, making them unsuitable for studying dynamic processes or characterizing essential genes, where chronic depletion can c...
ORGANISM(S): Homo sapiens 
2025-06-24 | GSE300048 | GEO
TranscriptomicsSystematic comparison and base-editing-mediated directed protein evolution and functional screening yield superior auxin-inducible degron technology [1]
Biological mechanisms are inherently dynamic, requiring precise and rapid manipulations for effective characterization. Traditional genetic manipulations operate on long timescales, making them unsuitable for studying dynamic processes or characterizing essential genes, where chronic depletion can c...
ORGANISM(S): Homo sapiens 
2025-06-26 | GSE300296 | GEO
OtherSystematic comparison and base-editing-mediated directed protein evolution and functional screening yield superior auxin-inducible degron technology [2]
Biological mechanisms are inherently dynamic, requiring precise and rapid manipulations for effective characterization. Traditional genetic manipulations operate on long timescales, making them unsuitable for studying dynamic processes or characterizing essential genes, where chronic depletion can c...
ORGANISM(S): Homo sapiens 
2025-06-26 | GSE300297 | GEO
ProteomicsNuclear speckles enable processing of RNA from GC-rich isochores
Nuclear speckles are conserved, membrane-less organelles linked to various post-transcriptional processes. Here, we examined their roles in human cells by engineered, acute removal of SON and SRRM2, two conserved speckle core components characterized by intrinsically disordered regions (IDRs). Their...
ORGANISM(S): Homo sapiens (Human) 
2026-02-25 | PXD009359 | Pride
GenomicsNuclear Speckles enable processing of RNA from GC-rich Isochores [SON_Halo_pSR_SF3B1_FLASH]
Nuclear Speckles enable processing of RNA from GC-rich Isochores [SON_Halo_pSR_SF3B1_FLASH]
PRJNA1101939 | ENA
Sort   by:  
 Page size