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ProteomicsTelomeric protein composition deriving from q-TIP analysis comparing Hela supertelomerase cells, Hela TRF2 knockdown cells or Hela POT1 knockdown cells with Hela control cells, proteomes by 2D-LC-MS/MS
All samples derived from the q-TIP experiments were analysed using reverse-phase chromatography coupled to orbitrap high-resolution mass spectrometer using trypsin digestion. MS/MS files were searched against the UniProt human protein database (release date 18-04-2012) by MaxQuant software (version ...
ORGANISM(S): Homo sapiens (Human) 
2013-11-26 | PXD000243 | Pride
Human Silac Telomer length Telomers Chromatin Lc-ms/ms 
ProteomicsHypoxic Incubation Conditions for Optimized Manufacture of Tenocyte-Based Active Substances of Homologous Standardized Transplant Products in Tendon Regenerative Medicine
Human fetal progenitor tenocytes (hFPT) produced in defined cell bank systems have recently been characterized and qualified as potential therapeutic cell sources in tendon regenerative medicine. In view of further optimizing the manufacture of the cell-based active substance, the effects of hypoxic...
ORGANISM(S): Homo sapiens (Human) 
2022-02-15 | PXD028359 | Pride
Proteomics Cell manufacture Hypoxia Standardized transplants Tendon affections Human progenitor tenocytes Regenerative medicine 
ProteomicsA mammalian transcription factor-specific peptide repository for targeted proteomics
Site-specific transcription factors (TFs) play an essential role in mammalian development and function as they are vital for the majority of cellular processes. Despite their biological importance, TF proteomic data is scarce in the literature, likely due to difficulties in detecting peptides as the...
ORGANISM(S): Mus musculus (Mouse) 
2015-01-23 | PXD001212 | Pride
Transcription factor Repository for targeted proteomics Proteotypic peptide selection Quantitative proteomics 
ProteomicsCharacterization of the surfaceome of the metal-reducing bacterium Desulfotomaculum reducens
Desulfotomaculum reducens strain MI-1 is a Gram-positive, sulfate-reducing bacterium also capable of reducing Fe(III). Metal reduction in Gram-positive bacteria is poorly understood. Here, we investigated Fe(III) reduction with lactate, a non-fermentable substrate, as the electron donor. Lactate con...
ORGANISM(S): Desulfotomaculum reducens (strain MI-1) 
2014-07-31 | PXD001072 | Pride
Desulfotomaculum reducens metal-reducing surfaceome 
ProteomicsQuantitative Mass Spectrometry Reveals Plasticity of Metabolic Networks in Mycobacterium smegmatis
Carbon metabolism in Mycobacterium smegmatis was analysed using reverse-phase chromatography coupled to orbitrap high-resolution mass spectrometer using trypsin digestion. MS/MS files were searched against the Mycobacterium smegmatis strain MC2-155 database Release 1 - July 2010 ) by MaxQuant softwa...
ORGANISM(S): Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155) 
2014-07-09 | PXD000253 | Pride
Metabolic pathways Dimethyl Mycobacterium smegmatis Carbon-sources Maxquant Lc-ms/ms 
ProteomicsAn updated proteomic analysis of Drosophila hemolymph after bacterial infection
Using an in-depth Mass Spectrometry based proteomics approach, we provide a comprehensive characterization of the hemolymphatic proteome of adult flies upon bacterial infection. We detected and quantified changes in abundance of several known immune regulators and effectors, including multiple antim...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2025-05-07 | PXD058897 | Pride
Serine proteases Hemolymph Mass spectrometry Immunity Mitochondria Drosophila melanogaster Antimicrobial peptides Toll pathway Lc-ms/ms Imd pathway 
ProteomicsProteome adaptations of the organohalide-respiring Desulfitobacterium hafniense to fermentative and various respiratory metabolisms
Desulfitobacterium hafniense was originally isolated for its ability to use organohalogens as terminal electron acceptors in the process of organohalide respiration (OHR). However, in contrast to obligate OHR bacteria, Desulfitobacterium spp. show a highly versatile energy metabolism with the capaci...
ORGANISM(S): Desulfitobacterium hafniense DCB-2 
2023-01-18 | PXD030393 | Pride
Desulfitobacterium hafniense strain dcb-2  energy metabolism  organohalide respiration  fermentation  quantitative proteomics  tandem mass tag labelling 
ProteomicsFunctional proteomics defines differential signaling networks of the oncogenic kinases Bcr-Abl p210 and p185
The two major isoforms of the oncogenic Bcr-Abl tyrosine kinase, p210 and p185, are expressed upon the Philadelphia chromosome translocation. p210 is the hallmark of chronic myelogenous leukemia, whereas p185 occurs in the majority of B-cell acute lymphoblastic leukemia. Differences in protein-prote...
ORGANISM(S): Mus musculus (Mouse) 
2017-01-31 | PXD005149 | Pride
Leukemia Bcr-abl tyrosine kinase Interactome Silac Phosphoproteome 
ProteomicsPhosphoproteomics and Morphology of Red Blood Cells treated by Protein-Tyrosine-Phosphatases Inhibitor
Phosphorylation of proteins is involved in cell functions, of which cytoskeleton organization. In particular, the phosphotyrosine (pY) has been reported to play a role in red blood cell (RBC) functions. During the storage of RBC in the context of transfusion medicine, cells suffer from storage lesio...
ORGANISM(S): Homo sapiens (Human) 
2024-01-26 | PXD039914 | Pride
Protein tyrosine phosphorylation Storage of red blood cells Kinase inhibitors Digital holographic microscopy Transfusion medicine. 
ProteomicsResistance mechanism to Notch inhibition and combination therapy in human T cell acute lymphoblastic leukemia
Gain-of-function mutations in NOTCH1 are among the most frequent genetic alterations in T cell acute lymphoblastic leukemia (T-ALL), making the Notch signaling pathway a promising therapeutic target for personalized medicine. Yet, a major limitation for long-term success of targeted therapy is relap...
ORGANISM(S): Homo sapiens (Human) 
2024-01-26 | PXD038908 | Pride
Combination therapies Pik3r1 Notch1 Resistance mechanisms T-all 
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