Sort   by:  
 Page size 
TranscriptomicsThe ion channel Trpc6a regulates the cardiomyocyte regenerative response to mechanical stretch
Myocardial damage caused for example by cardiac ischemia leads to ventricular volume overload resulting in increased stretch of the remaining myocardium. In adult mammals, these changes trigger an adaptive cardiomyocyte hypertrophic response which, if the damage is extensive, will ultimately lead to...
ORGANISM(S): Danio rerio 
2023-12-20 | E-MTAB-13603 | biostudies-arrayexpress
TranscriptomicsGene expression changes in the female zebrafish (Danio rerio) brain in response to acute exposure to methylmercury
Methylmercury (MeHg) is a potent neurotoxin and endocrine disruptor that accumulates in aquatic systems. Previous studies have shown suppression of hormone levels in both male and female fish, suggesting effects on gonadotropin regulation in the brain. We investigated the gene expression profile in ...
ORGANISM(S): Danio rerio 
2010-09-30 | E-GEOD-22662 | biostudies-arrayexpress
TranscriptomicsHypoxia induces myocardial regeneration in zebrafish
Conditional expression of dominant-negative HIF1a in zebrafish cardiomyocytes severely inhibits heart regeneration. To understand more about the mechanism, we performed microarray analysis of wildtype regenerating zebrafish and dnHIF1a regenerating zebrafish to determine which genes are regulated by...
ORGANISM(S): Danio rerio 
2013-01-15 | E-GEOD-39842 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Danio rerio livers following chronic waterborne copper exposure
Zebrafish exposed to 2 waterborne copper concentrations (8 & 15 ug/L) in softwater for 21 days. Fish were terminally sampled and livers extracted for RNA extraction and hybridization to micorarrays
ORGANISM(S): Danio rerio 
2009-09-01 | E-MEXP-2287 | biostudies-arrayexpress
TranscriptomicsMice Exposed in situ to Urban Air Pollution Exhibit Pulmonary Alterations in Lipid Droplet Synthesis Pathways
In the present study, we investigate pulmonary transcriptional responses in mice following exposure in situ to ambient air in a heavily polluted urban environment. Mature C57BL/CBA male mice were caged in sheds located in an urban area near two working steel mills and a major highway in Hamilton, On...
ORGANISM(S): Mus musculus 
2013-09-30 | E-GEOD-41698 | biostudies-arrayexpress
UnknownLowering cholesterol, blood pressure, or both to prevent cardiovascular events: results of 8.7 years of follow-up of Heart Outcomes Evaluation Prevention (HOPE)-3 study participants.
Not available
S-EPMC8370761 | biostudies-literature
TranscriptomicsComparison of genomic, morphological, and behavioral responses among fathead minnow (Pimephales promelas ) and zebrafish (Danio rerio) to acute RDX exposure
Paper Abstract. Extrapolating toxicological sensitivity information across species can require the use of highly conservative safety factors as prescribed by ecological risk assessment protocols. The objective of our study was to use multipule factors to understand the dynamics of stress responses ...
ORGANISM(S): Danio rerio 
2011-02-08 | E-GEOD-27067 | biostudies-arrayexpress
MetabolomicsFeatures of acute COVID-19 associated with post-acute sequelae of SARS-CoV-2 phenotypes: results from the IMPACC study
Post-acute sequelae of SARS-CoV-2 (PASC) is a significant public health concern. We describe Patient Reported Outcomes (PROs) on 590 participants prospectively assessed from hospital admission for COVID-19 through one year after discharge. Modeling identified 4 PRO clusters based on reported deficit...
2024-01-12 | MTBLS850 | MetaboLights
UnknownPhase I, Open-Label, Dose-Escalation/Dose-Expansion Study of Lifirafenib (BGB-283), an RAF Family Kinase Inhibitor, in Patients With Solid Tumors.
Not available
S-EPMC7325368 | biostudies-literature
TranscriptomicsGene expression analysis of hair cell regeneration in the zebrafish lateral line
Deafness due to the terminal loss of inner ear hair cells is one of the most common sensory diseases. However, non-mammalian animals (e.g. birds, amphibian and fish) regenerate damaged hair cells. In order to better understand the reasons underpinning such regeneration disparities in vertebrates, we...
ORGANISM(S): Danio rerio 
2014-03-26 | E-GEOD-56176 | biostudies-arrayexpress
Sort   by:  
 Page size