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TranscriptomicsExtensive alternative polyadenylation during zebrafish development
The post-transcriptional fate of messenger RNAs (mRNAs) is largely dictated by their 3' untranslated regions (3'UTRs), which are defined by cleavage and polyadenylation (CPA) of pre-mRNAs. We used poly(A)-position profiling by sequencing (3P-Seq) to map poly(A) sites at eight developmental stages an...
ORGANISM(S): Danio rerio 
2012-06-17 | E-GEOD-37453 | biostudies-arrayexpress
UnknownLessons from the COVID-19 pandemic and recent developments on the communication of clinical trials, publishing practices, and research integrity: in conversation with Dr. David Moher.
Not available
S-EPMC9383655 | biostudies-literature
TranscriptomicsTranscription profiling by array of adult zebrafish control and post-lesion retina to investigate the molecular determinants of retinal regeneration in adult vertebrate
Purpose: Investigate the molecular determinants of retinal regeneration in adult vertebrates by analyzing the gene expression profiles of control and post-lesion retina of adult zebrafish, a system that regenerates following injury. Methods: Gene expression profiles of zebrafish retina and brain wer...
ORGANISM(S): Danio rerio 
2005-09-16 | E-GEOD-3303 | biostudies-arrayexpress
GenomicsConserved Function of lincRNAs in Vertebrate Embryonic Development Despite Rapid Sequence Evolution
Thousands of large intervening non-coding RNAs (lincRNAs) have been identified in mammals. To better understand the evolution and functions of these enigmatic RNAs, we used chromatin marks, poly(A)-site mapping and RNA-Seq data, to identify more than 550 distinct lincRNAs in zebrafish. Although thes...
ORGANISM(S): Danio rerio 
2011-12-22 | E-GEOD-32880 | biostudies-arrayexpress
UnknownThe implementation and validation of the NoMAD during a complex primary care intervention.
Not available
S-EPMC9206734 | biostudies-literature
GenomicsWhole genome methylation profiling in developing and developed Zebrafish
DNA methylation is a dynamic process through which specific chromatin modifications can be stably transmitted from parent to daughter cells. A large body of work has suggested that DNA methylation influences gene expression by silencing gene promoters. However, these conclusions were drawn from data...
ORGANISM(S): Danio rerio 
2014-03-25 | E-GEOD-52110 | biostudies-arrayexpress
ProteomicsIncreased Hemodynamic Load in Early Embryonic Stages Alters Endocardial to Mesenchymal Transition
Normal blood flow is essential for proper heart formation during embryonic development, as abnormal hemodynamic load (blood pressure and shear stress) results in cardiac defects seen in congenital heart disease. However, the progressive detrimental remodeling processes that relate altered blood flow...
ORGANISM(S): Gallus Gallus (ncbitaxon:9031) 
2019-07-17 | MSV000084103 | MassIVE
UnknownHealth TAPESTRY Ontario: protocol for a randomized controlled trial to test reproducibility and implementation.
Not available
S-EPMC7427958 | biostudies-literature
TranscriptomicsTranscription profiling of zebrafish embryos injected with Ofd1 morphlino compared to wild type
Comparison of Ofd1 morphlino injected zebrafish embryos with wild type
ORGANISM(S): Danio rerio 
2008-12-01 | E-MEXP-1879 | biostudies-arrayexpress
TranscriptomicsDichlorvos exposure results in large scale disruption of energy metabolism in the liver of the zebrafish, Danio rerio
Background: Exposure to dichlorvos (DDVP), an organophosphorus pesticide, is known to result in neurotoxicity as well as other metabolic perturbations. However, the molecular causes of DDVP toxicity are poorly understood, especially in cells other than neurons and muscle cells. To obtain a better un...
ORGANISM(S): Danio rerio 
2015-11-05 | E-GEOD-66257 | biostudies-arrayexpress
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