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MetabolomicsExogenous L-Alanine promotes phagocytosis multidrug-resistant bacterial pathogens (L-Alanine-treated macrophage metabolomics)

Multidrug-resistant bacteria present a major threat to public health. Therefore, new drugs or approaches are urgently needed to manage and mitigate this threat. Here, we screen the molecular candidates that allow the survival of mice upon Vibrio parahaemolyticus infection by integrated p...

2024-09-26 | MTBLS7986 | MetaboLights
MetabolomicsTargeted rewiring of the rhizosphere metabolite-microbe axis restores phosphorus acquisition in inefficient citrus rootstocks
This study aimed to screen citrus rootstocks with contrasting phosphorus (P) efficiency. Seedlings were grown in P-deficient red soil-vermiculite substrate under greenhouse conditions. After 5 months cultivation, plant biomass, leaf P concentration, root architecture, rhizosphere available P and pho...
2026-10-22 | MTBLS15885 | MetaboLights
TranscriptomicsTranscription repressor HANABA TARANU (HAN) controls flower development via integrating multiple hormone actions, floral organ specification and GATA3 family auto-regulation
Plant inflorescence meristems and floral meristems possess specific boundary domains that result in floral organ separation, and in proper numbers of floral organs. HANABA TARANU (HAN) encodes a boundary-expressing GATA type zinc finger transcription factor that regulates shoot apical meristem organ...
ORGANISM(S): Arabidopsis thaliana 
2013-09-01 | E-GEOD-38658 | biostudies-arrayexpress
TranscriptomicsA metabolomics analysis of Salmonella infection
The interplay between pathogens and hosts has been studied for decades using targeted approaches such as the analysis of mutants and host immunological responses. Although much has been learned from such studies, they focus on individual pathways and fail to reveal the global effects of infection on...
ORGANISM(S): Mus musculus 
2011-02-08 | E-GEOD-21720 | biostudies-arrayexpress
MetabolomicsEffects of Platycodins Folium on Depression in Mice Based on a UPLC-Q/TOF-MS Serum Assay and Hippocampus Metabolomics
Major depressive disorder (MDD), also known as depression, is a state characterized by low mood and aversion to activity. Platycodins Folium (PF) is the dried leaf of Platycodon grandiflorum, with anti-inflammatory and antioxidative activities. Our previous research suggested that PF was rich in fla...
2020-06-03 | MTBLS952 | MetaboLights
TranscriptomicsMicro-RNAs in Adult Rat Liver are Refractory to 19 Hours Dioxin Exposure
Dioxin-like chemicals are well-known for their ability to upregulate expression of numerous genes via the AH receptor (AHR). However, recent transcriptomic analyses in several laboratories indicate that dioxin-like chemicals or AHR genotype itself also can downregulate levels of mRNAs encoded by nu...
ORGANISM(S): Rattus norvegicus 
2007-08-15 | E-GEOD-8467 | biostudies-arrayexpress
ProteomicsAcetylome analyses in the germinating rice seed
Seed germination is a complicated physiological process, during which structures of mitochondria and plastids are recovered, and metabolisms are re-activated (Han and Yang, 2015). It has been shown that metabolism reactivation is very important for rice germination (He et al., 2011b;Han et al., 2014...
ORGANISM(S): Oryza sativa (Rice) 
2016-01-26 | PXD002739 | Pride
Rice Seed germination Lysine acetylation 
TranscriptomicsMetabolomics reveals phospholipids as important nutrient sources during Salmonella growth in bile in vitro and in vivo
During the colonization of hosts, bacterial pathogens are presented with many challenges that must be overcome for colonization to successfully occur. This requires bacterial sensing of the surroundings and adaptation to the conditions encountered. One of the major impediments to pathogen colonizati...
ORGANISM(S): Mus musculus 
2011-07-06 | E-GEOD-30404 | biostudies-arrayexpress
UnknownAssociation between CYP2B6 polymorphism and acute leukemia in a Han population of Northwest China.
Not available
S-EPMC7216805 | biostudies-literature
ProteomicsMitochondrial L-2-hydroxyglutarate is a physiologic signaling metabolite
L-2-hydroxyglutarate (L-2-HG) is a low-abundance metabolite in mammals, due to the mitochondrial enzyme L-2-HG dehydrogenase (L2HGDH), which oxidizes L-2-HG to 2-oxoglutarate (2-OG) to prevent its accumulation. In humans lacking L2HGDH activity, L-2-HG builds up, leading to L-2-HG aciduria, a rare c...
ORGANISM(S): Mus musculus (Mouse) 
2026-03-31 | PXD054020 | Pride
Mitochondria Metabolism 2-og-dependent dioxygenases Metabolite signaling Gene expression regulation 
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