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ProteomicsConditions for maintenance of hepatocyte differentiation and function in 3D cultures
3D spheroid cultures of primary human hepatocytes (PHH) are used in studies of hepatic drug metabolism and toxicity. However, the 3D spheroids are maintained under different conditions, with possible cofounding results. Here we performed an in-depth analysis of how various culture conditions influen...
ORGANISM(S): Homo sapiens (Human) 
2022-02-17 | PXD024632 | Pride
Primary human hepatocyte culture Lc-ms/ms 
ProteomicsProteomic Profiling Reveals Age-Related Changes in Transporter Proteins in the Human Blood-Brain Barrier
The Blood-Brain Barrier (BBB) is a crucial, selective barrier that regulates the entry of molecules including nutrients, environmental toxins, and therapeutic medications into the brain. This function relies heavily on brain endothelial cell proteins, particularly transporters and tight junction pro...
ORGANISM(S): Homo sapiens (Human) 
2025-11-28 | PXD057192 | Pride
Human Lc-msms Brain microvessels Blood-brain barrier Transporters Maxquant Orbitrap Aging Ontogeny 
ProteomicsProteomics informed deconvolution of 3 cell lines
The project aimed to investigate the possibility to use proteomics data to deconvolute cell line proportions in mixed samples. Samples containing either HEK 293, Caco-2, or A549 cells and mixtures of the three cell lines was analysed using the total protein approach. This was then used for proteomic...
ORGANISM(S): Homo sapiens (Human) 
2023-10-24 | PXD027282 | Pride
Hek 293 A549 Caco-2 
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