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MetabolomicsFunctional analysis of isoprenoid precursors biosynthesis by quantitative metabolomics and isotopologue profiling

INTRODUCTION: Isoprenoids are amongst the most abundant and diverse biological molecules and are involved in a broad range of biological functions. Functional understanding of their biosynthesis is thus key in many fundamental and applicative fields, including systems biology, me...

2021-04-01 | MTBLS923 | MetaboLights
MetabolomicsHost-gut microbiota interactions shape parasite infections in farmed Atlantic salmon

Animals and their associated microbiota share long evolutionary histories. However, it is not always clear how host genotype and microbiota interact to affect phenotype. We applied a hologenomic approach to explore how host-microbiota interactions shape lifetime growth and parasite infection in f...

2024-01-24 | MTBLS8575 | MetaboLights
UnknownSpatial distribution of Plasmodium vivax Duffy Binding Protein copy number variation and Duffy genotype, and their association with parasitemia in Ethiopia.
Not available
S-EPMC11870341 | biostudies-literature
TranscriptomicsAmniotic fluid and necrotizing enterocolitis in preterm pigs
Preterm neonates are susceptible to gastrointestinal (GI) disorders such as necrotizing enterocolitis (NEC). Maternal milk, and especially colostrum, protects against NEC via growth promoting, immunomodulatory and antimicrobial factors. The fetal enteral diet, amniotic fluid (AF), contains similar b...
ORGANISM(S): Sus scrofa 
2010-05-06 | E-GEOD-13515 | biostudies-arrayexpress
MetabolomicsPrediction of complex phenotypes using the Drosophila melanogaster metabolome
Understanding the genotype-phenotype map and how variation at different levels of biological organization is associated are central topics in modern biology. Fast developments in sequencing technologies and other molecular omic tools enable researchers to obtain detailed information on variation at ...
2021-08-05 | MTBLS2060 | MetaboLights
UnknownIdentification and functional characterization of G6PC2 coding variants influencing glycemic traits define an effector transcript at the G6PC2-ABCB11 locus.
Not available
S-EPMC4307976 | biostudies-literature
UnknownLow-frequency and rare exome chip variants associate with fasting glucose and type 2 diabetes susceptibility.
Not available
S-EPMC4311266 | biostudies-literature
TranscriptomicsMethanobrevibacter smithii expression profiling
This SuperSeries is composed of the following subset Series: GSE25408: The pan-genome of the dominant human gut-associated archaeon, Methanobrevibacter smithii GSE25535: Expression data from an in vitro growth of Methanobrevibacter smithii PS Refer to individual Series
ORGANISM(S): Methanobrevibacter smithii ATCC 35061 
2011-11-07 | E-GEOD-25537 | biostudies-arrayexpress
ProteomicsGene editing reverses arrhythmia susceptibility in humanized PLN-R14del mice: modeling a European cardiomyopathy with global impact
Aims: A mutation in the phospholamban (PLN) gene, leading to deletion of Arg14 (R14del), has been associated with malignant arrhythmias and ventricular dilation. Identifying pre-symptomatic carriers with vulnerable myocardium is crucial because arrhythmia can result in sudden cardiac death, especial...
ORGANISM(S): Mus musculus (Mouse) 
2023-03-11 | PXD031612 | Pride
Phospholamban Mouse model Tmt R14del Cardiomyopathy Lc-ms/ms 
TranscriptomicsTranscription profiling of mouse interleukin-10-deficient model for inflammatory bowel disease in C57Bl/6J and C3H/HeJBir strain backgrounds
Abstract: Interleukin-10-deficient (Il10-/-) mice serve as a model for inflammatory bowel disease (IBD). The severity of colitis strongly depends on the inbred strain carrying the disrupted Il10 gene: C3H/HeJBir (C3) confers disease susceptibility, whereas C57BL/6J (B6) confers resistance. Genome-wi...
ORGANISM(S): Mus musculus 
2007-12-04 | E-GEOD-2172 | biostudies-arrayexpress
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