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TranscriptomicsRNA-seq of coding RNA from USP14 knockout human haploid (HAP1) cells
We performed a genome-scale screen for suppressors of interferon stimulated gene (ISG) expression in human haploid cells (HAP1). Ubiquitin specific peptidase 14 (USP14) was a significant hit. In order to validate USP14 as a regulator of ISG expression, we created knockouts of USP14 in HAP1 cells usi...
ORGANISM(S): Homo sapiens 
2017-07-25 | E-MTAB-5865 | biostudies-arrayexpress
TranscriptomicsRNA-seq of coding RNA from DDX6 knockout human haploid (HAP1) cells
We performed a genome-scale screen for suppressors of interferon stimulated gene (ISG) expression in human haploid cells (HAP1). DEAD-box helicase 6 (DDX6) was a significant hit. In order to validate DDX6 as a regulator of ISG expression, we created knockouts of DDX6 in HAP1 cells using CRISPR-Cas9 ...
ORGANISM(S): Homo sapiens 
2017-07-25 | E-MTAB-5867 | biostudies-arrayexpress
TranscriptomicsIllumina RNA-seq of polyA+ RNA from HAP1 cells
Illumina RNA-seq was performed on polyA+ RNA isolated from the human HAP1 cell line
ORGANISM(S): Homo sapiens 
2019-03-14 | E-MTAB-7757 | biostudies-arrayexpress
MetabolomicsThe efflux pump ABCC1/MRP1 constitutively restricts PROTAC sensitivity in cancer cells
Proteolysis targeting chimeras (PROTACs) are bifunctional molecules that induce selective protein degradation by linking an E3 ubiquitin ligase enzyme to a target protein. This approach allows scope for targeting “undruggable” proteins and several PROTACs have reached the stage of clinical candidate...
2025-07-17 | MTBLS11394 | MetaboLights
ProteomicsCell Surface Glycoengineering - HAP1 Cells
Cell Surface Glycoengineering of HAP1 Cells using CMP-Neu5Ac Derivatives
ORGANISM(S): Homo sapiens (Human) 
2022-06-26 | PXD024251 | Pride
Cell surface glycoengineering - hap1 cells 
TranscriptomicsGene expression analysis of human haploid cells (HAP1) depleted of SMARCB1 and SMARCA4
The aim of this study is to analyze the change in genome wide expression levels in HAP1 cells upon loss of SMARCB1, SMARCA4 or both these genes together. The SMARCB1 and SMARCA4 genes were the hits from a genome wide screen involving genetrap mutagenesis to find new players that are involved in sen...
ORGANISM(S): Homo sapiens 
2016-08-22 | E-GEOD-75515 | biostudies-arrayexpress
ProteomicsProteomic profiling of centrosomes isolated from HAP1 cells
Centrosomes are cytoplasmic membraneless organelles that comprise a pair of centrioles, and a pericentriolar material. We developed a new centrosome affinity capture method termed CAPture that achieves high-coverage proteomes from 20-30 million cells. Here we present CAPture-MS data from HAP1 cells ...
ORGANISM(S): Homo sapiens (Human) 
2023-10-17 | PXD043692 | Pride
Centrosome Human Hap1 
GenomicsChIPmentation of FKBP12(F36V)-ZNF24 HAP1 cells treated with dTAGv-1 to induce endogenous ZNF24 degradation
Human HAP1 cell lines with their endogenous ZNF24 gene tagged with an FKBP12(F36V) degron were treated with dTAGv-1 to induce endogenous ZNF24 degradation to study the role of ZNF24 on histone modifications.
ORGANISM(S): Homo sapiens 
2026-08-01 | E-MTAB-14699 | biostudies-arrayexpress
ProteomicsLFQ shotgun proteomic analysis of HAP1 NatC KO cells
The impact of NatC subunits NAA30, NAA35 and NAA38 on the human proteome (protein abundance). Analysis of HAP1 WT, NAA30 KO, NAA35 KO and NAA38 KO cells
ORGANISM(S): Homo sapiens (Human) 
2023-09-20 | PXD034104 | Pride
Hap1 cells Natc ko Lfq Shotgun Lc-ms/ms 
GenomicsChIP-seq of Pol III and H3K4me3 in HAP1 and HepG2 tRNA gene deletion clones and control clones
This dataset contains ChIP-seq data of H3K4me3 and Pol III in single cell-derived control and CRISPR/Cas9 induced tRNA gene deletion clones in human cancer cell lines HAP1 and HepG2. In this study, we looked into functional Cas9-induced on-target genomic alteration in our tRNA gene deletion clones, ...
ORGANISM(S): Homo sapiens 
2022-09-16 | E-MTAB-10651 | biostudies-arrayexpress
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