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ProteomicsBroad substrate scope C-C oxidation in cyclodipeptides catalysed by a flavin-dependent filament
Cyclic dipeptides are produced by organisms across all domains of life, with many exhibiting anticancer and antimicrobial properties. Oxidations are often key to their biological activities, particularly C-C bond oxidation catalyzed by tailoring enzymes including cyclodipeptide oxidases. These flavi...
ORGANISM(S): Nocardiopsis dassonvillei 
2025-01-06 | PXD058613 | Pride
Diketopiperazine Flavin Oxidation Cyclodipeptide Filament 
UnknownImpact of the OATP1B1 c.521T>C single nucleotide polymorphism on the pharmacokinetics of exemestane in healthy post-menopausal female volunteers.
Not available
S-EPMC5646416 | biostudies-literature
UnknownLeonurenones A-C: Labdane diterpenes from Leonotis leonurus.
Not available
S-EPMC3685147 | biostudies-literature
UnknownFluoroalkoxylated C-3 and C-9 (S)-12-bromostepholidine analogues with D1R antagonist activity.
Not available
S-EPMC10872833 | biostudies-literature
TranscriptomicsTranscription profiling of mouse embryonic fibroblasts (MEF) from wild type vs CHOP-/- genotypes treated with tunicamycin reveals CHOP induces death by promoting protein synthesis and oxidation in the stressed endoplasmic reticulum
Primary mouse embryonic fibroblasts (pass 3 to 4) were treated with tunicamycin (2 micrograms/ml) for specified times - genotypes were WILDTYPE and CHOP-/-. Each time point n=4. C/EBP homologous protein CHOP is activated by ER stress, and CHOP deletion protects against its lethal consequences.
ORGANISM(S): Mus musculus 
2007-12-11 | E-GEOD-2082 | biostudies-arrayexpress
UnknownSynthesis of C-Homoaporphines via Microwave-Assisted Direct Arylation.
Not available
S-EPMC3050508 | biostudies-literature
TranscriptomicsISR target genes in the liver of mock-injected and AP20187-treated mice of wildtype and Atf4-/- genotype
The molecular mechanisms linking the stress of unfolded proteins in the endoplasmic reticulum (ER stress) to glucose intolerance in obese animals are poorly understood. In this study enforced expression of a translation initiation 2α (eIF2α)-specific phosphatase, GADD34, was used to selectively comp...
ORGANISM(S): Mus musculus 
2011-12-23 | E-GEOD-11116 | biostudies-arrayexpress
TranscriptomicsTranscriptional profiling of Populus leaves with altered SA levels
Salicylic acid (SA) has long been implicated in plant responses to oxidative stress. A direct assessment of SA effects in planta has been difficult, as SA-overproducing Arabidopsis mutants are compromised in growth or other developmental processes. We now report that transgenic Populus expressing ...
ORGANISM(S): Populus tremula x Populus alba 
2013-08-01 | E-GEOD-42511 | biostudies-arrayexpress
Unknownc-Src activation as a potential marker of chemical-induced skin irritation using tissue-engineered skin equivalents.
Not available
S-EPMC10946902 | biostudies-literature
UnknownRisk communication in tables versus text: a registered report randomized trial on 'fact boxes'.
Not available
S-EPMC7137953 | biostudies-literature
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