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TranscriptomicsAmino acid deprivation due to overexpression of UCP1 in skeletal muscle: signalling via FGF-21
Recent studies on mouse and human skeletal muscle (SM) demonstrated the important link between mitochondrial function and the cellular metabolic adaptation. To identify key compensatory molecular mechanisms in response to chronic mitochondrial distress, we analyzed mice with ectopic SM respiratory u...
ORGANISM(S): Mus musculus 
2015-02-17 | E-GEOD-45991 | biostudies-arrayexpress
MetabolomicsA conserved metabolic signature associated with response to fast-acting antimalarial agents

Characterizing the mode of action of antimalarial compounds that emerge from high-throughput phenotypic screens is central to understanding how parasite resistance to these drugs can emerge. Here, we have employed untargeted metabolomics to inform on the mechanism of action of antimalarial leads ...

2023-09-27 | MTBLS6580 | MetaboLights
TranscriptomicsChip-on-chip analysis of direct Nkx2.1 target genes in proliferating and differentiating epithelium in mouse lung development.
Nkx2.1 is a critical regulator of mammalian lung development. It is expressed in epithelial cells at the initiation of lung organogenesis, becoming progressively restricted during development to bronchiolar and alveolar type II epithelial cells. In humans, it is a common marker of carcinomas of lung...
ORGANISM(S): Mus musculus 
2011-11-01 | E-GEOD-23043 | biostudies-arrayexpress
MetabolomicsEffect of glycerol feed-supplementation on seabass metabolism and gut microbiota

Dietary glycerol supplementation in aquaculture feed is seen as an alternative and inexpensive way to  fuel fish metabolism, attenuate metabolic utilization of dietary proteins and, subsequently reduce nitrogen  excretion. In this study, we evaluated the impact of dietary glycerol suppl...

2020-07-30 | MTBLS870 | MetaboLights
UnknownWhole-exome sequencing of the BDR cohort: evidence to support the role of the PILRA gene in Alzheimer's disease.
Not available
S-EPMC6005734 | biostudies-literature
TranscriptomicsExpression analysis of Gordonia sp. KTR9 and Gordonia sp. KTR9 mutant GlnR upon exposure to high and low Nitrogen conditions
Investigation of gene expression level changes in Gordonia sp. KTR9 and Gordonia sp. KTR9 mutant GlnR upon exposure to high and low nitrogen conditions The Gordonia sp. KTR9 strain used in this study has been previously described by Thompson KT, Crocker FH, Fredrickson HL.2005. Mineralization of the...
ORGANISM(S): Gordonia sp. KTR9 
2013-02-06 | E-GEOD-42341 | biostudies-arrayexpress
UnknownComparison of the EPIC Physical Activity Questionnaire with combined heart rate and movement sensing in a nationally representative sample of older British adults.
Not available
S-EPMC3916297 | biostudies-literature
UnknownAlzheimer's disease polygenic risk score as a predictor of conversion from mild-cognitive impairment.
Not available
S-EPMC6534556 | biostudies-literature
TranscriptomicsCharacterization of the SigB-PrfA regulatory network in Listeria monocytogenes
Listeria monocytogenes SigB and PrfA are pleiotropic regulators of stress response and virulence gene expression, which have been shown to co-regulate genes in L. monocytogenes. We performed whole genome transcriptional profiling in the presence of PrfA* and active SigB, to identify the overlaps be...
ORGANISM(S): Listeria monocytogenes 
2010-05-19 | E-GEOD-11347 | biostudies-arrayexpress
UnknownGenetic variability in response to amyloid beta deposition influences Alzheimer's disease risk.
Not available
S-EPMC7145452 | biostudies-literature
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