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MetabolomicsMetabolomics reveals impaired maturation of HDL particles in adolescents with hyperinsulinaemic androgen excess
Hyperinsulinaemic androgen excess (HIAE) in prepubertal and pubertal girls usually precedes a broader pathological phenotype in adulthood that is associated with anovulatory infertility, metabolic syndrome and type 2 diabetes. The metabolic derangements that determine these long-term health risks re...
2015-04-09 | MTBLS103 | MetaboLights
MetabolomicsFunctional analysis of isoprenoid precursors biosynthesis by quantitative metabolomics and isotopologue profiling

INTRODUCTION: Isoprenoids are amongst the most abundant and diverse biological molecules and are involved in a broad range of biological functions. Functional understanding of their biosynthesis is thus key in many fundamental and applicative fields, including systems biology, me...

2021-04-01 | MTBLS923 | MetaboLights
TranscriptomicsTranscription profiling of human right ventricular samples acquired during cardiac surgery
Right ventricular samples were serially acquired during surgical repair of ventricular septal defect. Expression profiling revealed three patterns of gene expression: (1) increased expression above control levels within one hour of cardioplegic arrest, with further amplification during early reperfu...
ORGANISM(S): Homo sapiens 
2008-06-14 | E-GEOD-6381 | biostudies-arrayexpress
TranscriptomicsRNA sequencing of ILK-deficient hair follicle bulge stem cells
We sequenced mRNA from FACS purified hair follicle bulge stem cells from 21 d old control and ILK-deficient mice, 3 biological replicates each Examination of mRNA levels in control and ILK-deficient hair follicle bulge stem cells
ORGANISM(S): Mus musculus 
2015-09-01 | E-GEOD-68846 | biostudies-arrayexpress
TranscriptomicsArabidopsis thaliana Growth is Negatively Regulated by the Class III Peroxidase AtPrx71 during Development and in Response to Cell Wall Damage
The cell wall is a crucial structure in plant cells, and modifications in its composition often have a major impact on growth and development. However, the molecular mechanisms responsible for the negative effects of cell wall alterations on plant growth are largely unknown. It was previously shown ...
ORGANISM(S): Arabidopsis thaliana 
2016-01-06 | E-GEOD-66980 | biostudies-arrayexpress
TranscriptomicsBulk RNA sequencing of cardiomyocytes differentiated in monolayer (2D) from hiPSC-derived cell lines with tetracycline-inducible knockdown of CTCF and GATA4
This dataset was generated to study the role of the DNA-binding factors CTCF and GATA4 in cardiac specification. Three WTC11-derived hiPSC lines were used, each carrying a stably integrated shRNA construct. Two constructs specifically target CTCF and GATA4, while the third expresses a scrambled, non...
ORGANISM(S): Homo sapiens 
2025-10-14 | E-MTAB-15684 | biostudies-arrayexpress
TranscriptomicsBulk RNA sequencing of cardiac organoids differentiated from hiPSC-derived cell lines with knockdown of factors involved in early cardiac specification
This dataset was generated to investigate the role of two DNA-binding factors, CTCF and GATA4, in early cardiac specification. Three WTC11-derived hiPSC lines were employed, each carrying a stably integrated shRNA construct. Two of the constructs specifically target CTCF and GATA4, while the third e...
ORGANISM(S): Homo sapiens 
2025-10-14 | E-MTAB-15710 | biostudies-arrayexpress
TranscriptomicsINCISE Mutational Data Subset: Index, Metachronous, and Synchronous Polyps
This study used formalin-fixed paraffin-embedded (FFPE) human tissue collected for the Integrated teChnologies for Improved polyp SurveillancE (INCISE) collaborative from polypectomies performed within the Scottish BCSP in the NHS Greater Glasgow and Clyde health board between 2009-2016 in patients ...
ORGANISM(S): Homo sapiens 
2025-10-10 | E-MTAB-15619 | biostudies-arrayexpress
TranscriptomicsINCISE Mutational Data Subset
This study used formalin-fixed paraffin-embedded (FFPE) human tissue collected for the Integrated teChnologies for Improved polyp SurveillancE (INCISE) collaborative from polypectomies performed within the Scottish BCSP in the NHS Greater Glasgow and Clyde health board between 2009-2016 in patients ...
ORGANISM(S): Homo sapiens 
2025-07-31 | E-MTAB-15346 | biostudies-arrayexpress
TranscriptomicsStorage time does not modify the gene expression profile of cryopreserved human metaphase II oocytes
Study question: Does storage time impact on transcriptome of slowly frozen cryopreserved human metaphase II (MII) oocytes? Summary answer: For the first time, we demonstrate that the length of cryostorage has no effect on the gene expression profile of human metaphase II oocytes. What is known alrea...
ORGANISM(S): Homo sapiens 
2015-09-19 | E-GEOD-69768 | biostudies-arrayexpress
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