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TranscriptomicsTranscription profiling of skeletal and cardiac muscles in dysferlin-deficient SJL/J mice and wild type mice to understand the protective mechanisms against dysferlin deficiency in cardiac muscles.
Dysferlin is expressed in skeletal and cardiac muscle. However, dysferlin deficiency, namely limb girdle muscular dystrophy 2B (LGMD2B) and Myoshi myopathy, results in skeletal muscle weakness and spares the heart. This dichotomy could be caused by differential regulation of protective mechanisms. T...
ORGANISM(S): Mus musculus 
2007-09-04 | E-GEOD-2507 | biostudies-arrayexpress
UnknownChanges In County-Level Access To Medications For Opioid Use Disorder After Medicare Coverage Of Methadone Treatment Began.
Not available
S-EPMC11332379 | biostudies-literature
MetabolomicsMulti-dimensional leaf phenotypes reflect root system genotype in grafted grapevine over the growing season

BACKGROUND: Modern biological approaches generate volumes of multi-dimensional data, offering unprecedented opportunities to address biological questions previously beyond reach owing to small or subtle effects. A fundamental question in plant biology is the extent to which below...

2022-01-07 | MTBLS2831 | MetaboLights
UnknownCirculating microRNA expression profiles associated with systemic lupus erythematosus.
Not available
S-EPMC6662589 | biostudies-literature
UnknownToward a Mechanistic Understanding of Environmentally Forced Zoonotic Disease Emergence: Sin Nombre Hantavirus.
Not available
S-EPMC4776718 | biostudies-literature
ProteomicsIdentification of biomarkers for PKD1 using urinary exosomes
Autosomal dominant polycystic kidney disease (ADPKD) is a common cause of ESRD. Affected individuals inherit a defective copy of either the PKD1 or PKD2 gene, encoding the proteins polycystin?1 (PC1) or polycystin?2 (PC2) respectively. PC1 and PC2 are secreted on urinary exosome?like vesicles (ELVs)...
ORGANISM(S): Homo sapiens (Human) 
2014-12-02 | PXD001075 | Pride
Exosomes Exosome-like vesicles Pkd Adpkd Autosomal dominant polycystic kidney disease Urine 
UnknownWhole-genome sequencing of Atacama skeleton shows novel mutations linked with dysplasia.
Not available
S-EPMC5880234 | biostudies-literature
MetabolomicsMetabolic profiling of maternal serum of women at high-risk of spontaneous preterm birth using NMR and MGWAS approach
Preterm birth (PTB) is a leading global cause of infant mortality. Risk factors include genetics, lifestyle choices and infection. Understanding the mechanism of PTB could aid the development of novel approaches to prevent PTB. This study aimed to investigate the metabolic biomarkers of PTB in early...
2023-05-24 | MTBLS1990 | MetaboLights
MetabolomicsAnalysis of sex-specific lipid metabolism of Plasmodium falciparum points to the importance of sphingomyelin for gametocytogenesis
Male and female Plasmodium falciparum gametocytes are the parasite lifecycle stage responsible for transmission of malaria from the human host to the mosquito vector. Not only are gametocytes able to survive in radically different host environments, but they are also precursors for male and female g...
2022-04-05 | MTBLS4137 | MetaboLights
UnknownBenefits of Peer Support for Intensive Care Unit Survivors: Sharing Experiences, Care Debriefing, and Altruism.
Not available
S-EPMC8182973 | biostudies-literature
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