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ProteomicsPhosphoproteomic analysis of calcium signaling
Calcium signaling plays a pivotal role in t cell activation through activation of kinases and phosphatases, but comprehensive analysis to overview calcium-induced phosphorylation has never been performed. To investigate Ca2+-mediated phosphorylation globally, we next undertook a phosphoproteomic ana...
ORGANISM(S): Mus musculus (Mouse) 
2022-02-22 | PXD000973 | Pride
Calcium signaling Mouse thymocytes Calcineurin Itraq 
ProteomicsPhosphoproteomic analysis of TCR signaling with inhibitors
MAPK-Erk and calcium-Calcineurin pathways are major signaling pathways activated during TCR signal transduction. We investigated the effect of these signaling pathway with the use of selective inhibitors of Mek and calcineurin.
ORGANISM(S): Mus musculus (Mouse) 
2022-02-22 | PXD000972 | Pride
Tcr signaling Calcineurin inhibitor Mek inhibitor 
ProteomicsQuantitative phosphoproteomic analysis of TCR signaling
To define the physiological properties of TCR signaling, We investigated the global dynamic view of TCR-dependent phosphorylation with the use of thymocytes stimulated with antibodies to CD3 to mimic TCR activation
ORGANISM(S): Mus musculus (Mouse) 
2022-02-22 | PXD000969 | Pride
Tcr singaling Quantitiative phosphoproteome Mouse thymocytes 
ProteomicsThymocyte quantitation test
To evalute our phospho-iTRAQ system, which combined with IMAC and iTRAQ, with respect to the efficiency of concentration of phosphorylation and quantitation accuracy
ORGANISM(S): Mus musculus (Mouse) 
2022-02-22 | PXD000910 | Pride
Thymocyte 
ProteomicsProteomics in rat skeletal muscle after electrical stimulation-induced resistance exercise
We performed transcutaneous electrode stimulation to the tibialis anterior (TA) muscle of rats to mimic resistance exercise and mass spectrometer to measure the changes in protein expression following exercise. Wistar male rats (11-week-old) reared at room temperature (21-25°C) on a 12:12 h light-da...
ORGANISM(S): Rattus Norvegicus 
2024-11-20 | PXD056315 | JPOST Repository
ProteomicsProteome analysis of mouse oocytes and pre-implantation embryos
Mouse oocytes and embryos from the germinal vesicle (GV) stage to the blastocyst stage were collected and treated with acidic Tyrode’s solution to remove the zona pellucida. We used 42.5 oocytes or embryos per sample at each developmental stage and identified the proteome during mouse pre-implantati...
ORGANISM(S): Mus Musculus (mouse) 
2025-05-22 | PXD059122 | JPOST Repository
UnknownThe ASC-1 complex promotes translation initiation by scanning ribosomes
Not available
S-SCDT-10_15252-EMBJ_2022112869 | biostudies-other
ProteomicsProteome analysis of mouse Wdr74-knockout embryos
Mouse Wdr74-knockout embryos were generated using the CRISPR-Cas9 system. Embryos from the 4-cell stage to the morula stage were collected and treated with acidic Tyrode's solution to remove the zona pellucida. We used 50 embryos per sample at each developmental stage and identified the proteome of ...
ORGANISM(S): Mus Musculus (mouse) 
2025-05-22 | PXD059124 | JPOST Repository
ProteomicsPhosphoproteome data of WT and ob/ob mice liver during starvation
Ten-week-old male mice (WT and ob/ob) were starved for 0, 2, 4, 6, 8, 12, 16, and 24 hours and liver samples were collected. Total proteins extracted during sample preparation of metabolomic analysis were subjected to the following phosphoproteomic analysis. As described above, 2 mg of protein solut...
ORGANISM(S): Mus Musculus (mouse) 
2025-05-20 | PXD053026 | JPOST Repository
ProteomicsProteome analysis of brain vessels (the anterior cerebral artery and the middle cerebral artery) from 24-month-old Htra1 KO and wild type mice
CARASIL (cerebral autosomal recessive arteriopathy with subcortical infarcts and leukoencephalopathy) is a hereditary cerebral small-vessel disease caused by loss of function mutations of HTRA1, which is a serine protease with a variety of targets, including extracellular matrix proteins. We isolate...
ORGANISM(S): Mus Musculus (mouse) 
2021-11-02 | PXD022298 | JPOST Repository
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