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TranscriptomicsThe blood transcriptional signature of chronic HCV
This SuperSeries is composed of the following subset Series: GSE40184: The blood transcriptional signature of chronic HCV [Affymetrix data] GSE40223: The blood transcriptional signature of chronic HCV [Illumina data] Refer to individual Series
ORGANISM(S): Homo sapiens 
2012-10-22 | E-GEOD-40224 | biostudies-arrayexpress
TranscriptomicsThe blood transcriptional signature of chronic HCV [Affymetrix data]
This study characterizes the effects of chronic Hepatitis C virus (HCV) infection on gene expression by analyzing blood samples from 10 treatment-naive HCV patients and 6 healthy volunteers. Differential expression analysis of microarray data from peripheral blood mononuclear cells (PBMCs) identifie...
ORGANISM(S): Homo sapiens 
2012-10-22 | E-GEOD-40184 | biostudies-arrayexpress
TranscriptomicsEndogenous Intrahepatic Interferons and Association with IFN-free HCV Treatment Outcome
Hepatitis C virus (HCV) chronically infects 170 million people worldwide and is a leading cause of liver-related mortality due to hepatocellular carcinoma and cirrhosis1. Standard-of-care treatment is shifting from interferon-alpha (IFNM-NM-1)-based to IFNM-NM-1-free directly acting antiviral (DAA)...
ORGANISM(S): Homo sapiens 
2014-08-15 | E-GEOD-51699 | biostudies-arrayexpress
TranscriptomicsHepatic gene expression of HCV related Hepatocellular carcinoma and non-cancerous tissue with Il28B rs8099917 TT genotype and TG/GG genotype
IL28B genotype was shown to be associated with treatment outcome of antiviral thearpy for HCV infection. We tried to clarify the molecular feature that was associated with IL2B genotype by comparing Hepatic gene expression of HCV related Hepatocellular carcinoma and non-cancerous tissue with Il28B r...
ORGANISM(S): Homo sapiens 
2013-05-02 | E-GEOD-41804 | biostudies-arrayexpress
TranscriptomicsCpG site methylation of HCV-cirrhotic, HCV-HCC, and normal liver tissues
In this study we used a high-throughput method for assaying methylation of CpG sites simultaneously in a single sample for identifying differences in methylation observed in tissues ranging from normal liver to pre-neoplastic (cirrhosis) and neoplastic (HCC) states. Since there are important clinica...
ORGANISM(S): Homo sapiens 
2010-02-18 | E-GEOD-18081 | biostudies-arrayexpress
ProteomicsHepatitis C-like viruses are produced in cells from rabbit and hare DNA
Hepatitis C virus (HCV), a major causative agent of acute and chronic liver disease, belongs to the Flaviviridæ family and contains a single-strand positive-sense RNA genome, which upon virus entry and uncoating, functions as mRNAs and thus can be directly translated into proteins by host cell machi...
ORGANISM(S): Hepatitis C virus 
2016-01-21 | PXD001992 | Pride
Rhcv Rabbit Hhcv Dna Hare Hcv Maldi-tof/tof 
TranscriptomicsExpression data in human hepatocytes with HCV infection
Human hepatocyte chimeric mice were prepared and treated with hepatitis C virus (HCV) and/or interferon-alpha (IFN-α). To analyze the changes in gene expression, cDNA microarray analysis was performed with the collected human hepatocytes from the chimeric mouse livers. We consider that these result...
ORGANISM(S): Homo sapiens 
2012-05-02 | E-GEOD-37715 | biostudies-arrayexpress
TranscriptomicsDifferential expression associated with GB virus C in HCV/HIV co-infection
The aim of this study was to identify differential gene and protein expression associated with GBV-C that may be of importance in reduction of HCV-related liver disease. GB virus C (GBV-C) infection leads to improved outcomes in human immunodeficiency virus (HIV) infection. Furthermore, GBV-C has be...
ORGANISM(S): Homo sapiens 
2011-05-10 | E-GEOD-16593 | biostudies-arrayexpress
TranscriptomicsGene expression profiling in HCV associated liver disease. This dataset is part of the TransQST collection.
Expression of human genes was compared in liver fibrosis stage F1, F2, F3, and F4 to find markers that can differentiate among each fibrosis stages and cirrhosis. Four- condition experiment, F1 vs. F2 vs. F3 vs. F4. Biological replicates: 3 Normal, 3 F1, 3 F2, 3 F3 and 3 F4 stage samples.
ORGANISM(S): Homo sapiens 
2011-11-21 | E-GEOD-33258 | biostudies-arrayexpress
TranscriptomicsTrancription profiling of the hepatoma cell line Huh7 infected with the Hepatitis C Virus
Hepatitis C Virus is a leading cause of chronic liver disease. The identification and characterisation of key host cellular factors that play a role in the HCV replication cycle is important for the understanding of disease pathogenesis and the identification of novel anti-viral therapeutic targets....
ORGANISM(S): Homo sapiens 
2010-05-27 | E-GEOD-20948 | biostudies-arrayexpress
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