Sort   by:  
 Page size 
TranscriptomicsNociceptor HDAC4 regulates inflammatory pain
Transcriptional alterations are characteristic of persistent pain states but the key regulators remain elusive. Using a conditional knockout (cKO) strategy in mice we sought to determine whether loss of the transcriptional co-repressor histone deacetylase four (HDAC4) would have implications for sen...
ORGANISM(S): Mus musculus 
2015-04-23 | E-GEOD-62405 | biostudies-arrayexpress
ProteomicsHdac4 interactome in Huntington's Disease
Hdac4 has been found to modulate symptoms in Huntington's Disease (HD) mouse models through an uknown mechanism unrelated to any enzymatic activity. We investigated the protein-protein interactions to gain insight into the role of Hdac4 in HD.
ORGANISM(S): Mus musculus (Mouse) 
2019-05-01 | PXD011845 | Pride
Ap-ms Striatum Hdac4 Hdac5 Mouse brain Interactome 
TranscriptomicsGene expression data from mouse HDAC4 KO pups, postnatal day 3
Reversible protein acetylation provides a central mechanism for controlling gene expression and cellular signaling events. It is governed by the antagonistic commitment of two enzymes families: the histone acetyltransferases (HATs) and the histone deacetylases (HDACs). HDAC4, like its class IIa coun...
ORGANISM(S): Mus musculus 
2014-07-30 | E-GEOD-49383 | biostudies-arrayexpress
ProteomicsHDAC4 interactors identified by MS/MS
Access to DNA is the first level of control in regulating gene transcription, a control that is also critical for maintaining DNA integrity. Cellular senescence is characterized by profound transcriptional rearrangements and accumulation of DNA lesions. Here, we discovered an epigenetic complex betw...
ORGANISM(S): Homo sapiens (Human) 
2024-10-17 | PXD051316 | Pride
Hdac4  senescence  ms/ms 
GenomicsIdentification of histone modifications in cardiomyocytes of conditional HDAC4 knockout mice
Histone Deacetylase 4 (HDAC4) is known to contribute to cardiac remodeling processes. We wanted to identify and compare different genome wide targets of HDAC4 to well described interaction partners and its functional consequences. Therefore, we used a model of adult cardiomyocytes isolated from HDAC...
ORGANISM(S): Mus musculus 
2021-09-15 | E-MTAB-7319 | biostudies-arrayexpress
TranscriptomicsHDAC4 reduction: a novel therapeutic strategy to target cytoplasmic huntingtin and ameliorate neurodegeneration
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Mus musculus 
2014-10-10 | E-GEOD-38237 | biostudies-arrayexpress
GenomicsExploring the downstream genes of HDAC4
Exploring the downstream genes of HDAC4
PRJNA517431 | ENA
GenomicsChIP-seq analysis about Hdac4/5 samples
ChIP-seq analysis about Hdac4/5 samples
PRJNA737433 | ENA
TranscriptomicsTranscriptome profiling of human urothelial carcinoma cell lines RT-112, VM-Cub-1, SW1710, UMUC3 and a benign urothelial control HBLAK engineered to stably express HDAC5 against their vector control
Aberrant expression of histone deacetylases (HDACs) and their activity are associated with a broad range of tumor development. However, based on cell or tissue types, class IIA HDACs such as HDAC4 and HDAC5 may facilitate or inhibit cancer progression. The goal of this project is to examine the gene...
ORGANISM(S): Homo sapiens 
2019-11-13 | E-MTAB-8418 | biostudies-arrayexpress
TranscriptomicsSingle cell sequencing of iPSC-dopamine neurons reconstructs disease progression and identifies HDAC4 as a regulator of Parkinson cell phenotypes
Induced pluripotent stem cell (iPSC)-derived dopamine neurons provide an opportunity to model Parkinson’s disease (PD) but neuronal cultures are confounded by cellular heterogeneity. By applying high-resolution single cell transcriptomic analyses to Parkinson’s iPSC-derived dopamine neurons carrying...
ORGANISM(S): Homo sapiens 
2018-10-17 | E-MTAB-7303 | biostudies-arrayexpress
Sort   by:  
 Page size