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MetabolomicsTranscript variants of long-chain acyl-CoA synthase 1 have distinct roles in sheep lipid metabolism
Mutton has recently been identified to be a consumer favorite, and intermuscular fat is the key factor in determining meat tenderness. Long-chain acyl-CoA synthetase 1 (ACSL1) is a vital subtype of the ACSL family that is involved in the synthesis of lipids from acyl-CoA and the oxidation of fatty a...
2023-02-06 | MTBLS5808 | MetaboLights
TranscriptomicsLivers from lean or fat muscle lines fed low or high lipid diets
We used fish from two divergent lines of rainbow trout, selected for low or high muscle fat content (respectively L and F lines) and fed two different diets, containing either 10% (LE diet) or 23% (HE diet) lipids. For more details about experimental fish and diets, see Kolditz et al.,Am J Physiol R...
ORGANISM(S): Oncorhynchus mykiss 
2008-09-01 | E-GEOD-12031 | biostudies-arrayexpress
MetabolomicsThe effects of oligomycin administration and glutamine deprivation on metabolic profile of MCF7 breast cancer cell line measured using [1,2-13C2]-D-glucose and [U-13C5]-L-glutamine as tracers
This study aims to establish a comprehensive, genome-scale metabolic model (GSMM) combining different omics data of different regulatory levels of breast cancer cells in order to elucidate the way that these regulatory levels affect or determine each other. Together with transcriptomics, proteomics ...
2021-01-18 | MTBLS183 | MetaboLights
ProteomicsMaternal nutrition modulates fetal development through inducing placental efficiency changes in gilts
Intra-uterine growth restriction (IUGR) and fetal overgrowth increase the risk of postnatal health. Maternal nutrition is the major intrauterine environmental factor that alters fetal weight. However, the mechanisms underlying maternal nutrition affect fetal development is not entirely clear. We dev...
ORGANISM(S): Sus scrofa domesticus (domestic pig) 
2018-10-26 | PXD004951 | Pride
Fetal weight Energy level Itraq Gilts Placenta 
TranscriptomicsComprehensive identification of long non-coding RNAs expressed during zebrafish embryogenesis [RNA_seq]
Long non-coding RNAs (lncRNAs) comprise a diverse class of transcripts that structurally resemble mRNAs but do not encode proteins. Recent genome-wide studies in human and mouse have annotated lncRNAs expressed in cell lines and adult tissues, but a systematic analysis of lncRNAs expressed during ve...
ORGANISM(S): Danio rerio 
2011-11-17 | E-GEOD-32898 | biostudies-arrayexpress
ProteomicsT he proteostasis interactomes of trafficking - deficient K V 11.1 variants associated with Long QT Syndrome and pharmacological chaperone rescue
The voltage gated potassium ion channel KV11.1 plays a critical role in cardiac repolarization. Genetic variants that render Kv11.1 dysfunctional cause Long QT Syndrome (LQTS), which is associated with fatal arrhythmias. Approximately 90% of LQTS-associated variants cause intracellular protein trans...
ORGANISM(S): Homo sapiens (Human) 
2024-08-10 | PXD050914 | Pride
Herg Long qt syndrome Ion channel Trafficking K v 11.1 Interactome 
TranscriptomicsMicroarray-based global mapping of integration sites of retrotransposon, intracisternal A-particle, in mouse genome
Mammalian genomes have evolutionary harbored numerous mobile elements, a part of which are still active and evoke genomic instability. Their movement and positional diversity occasionally result in phenotypic changes and variation by causing altered expression and disruption of neighboring genes in...
ORGANISM(S): Mus musculus 
2008-05-03 | E-GEOD-9572 | biostudies-arrayexpress
TranscriptomicsLong noncoding RNA expression during human B-cell development
Long noncoding RNAs (lncRNAs) have emerged as important regulators of diverse cellular processes, but their roles in the developing immune system are poorly understood. In this study, we analysed lncRNA expression during human B-cell development by array-based expression profiling of eleven distinct...
ORGANISM(S): Homo sapiens 
2016-02-09 | E-GEOD-69033 | biostudies-arrayexpress
TranscriptomicspH stress in Desulfovibrio vulgaris Hildenborough
Using data from microarray experiments, we investigated the effects of excess NaCl on D. vulgaris. Keywords: stress response, time course Comparison of cells treated with pH10 pH to untreated cells at times of 0,120,240,30,60 min.
ORGANISM(S): Desulfovibrio vulgaris str. Hildenborough 
2007-08-31 | E-GEOD-8197 | biostudies-arrayexpress
TranscriptomicsAcetone stress response in Desulfovibrio vulgaris
Desulfovibrio vulgaris has been studied extensively for its potential in the bioremediation of heavy metals and radionuclides. Hydrocarbons and solvents, as frequent environmental co-contaminants, have been reported to inhibit microbial activities and thereby pose a limitation on bioremediation effi...
ORGANISM(S): Desulfovibrio vulgaris str. Hildenborough 
2009-08-08 | E-GEOD-5569 | biostudies-arrayexpress
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