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TranscriptomicsNext Generation Sequencing Facilitates Quantitative Analysis of miRNAs in hepatic fibrosis and normal tissues.
Aim: Hepatic fibrosis is a major worldwide medical problem and can develop into liver cirrhosis and hepatocellular carcinoma(HCC). Until now, there are no effective drugs for liver ?brosis because the molecular mechanism of progression of liver fibrosis is not fully understood. MicroRNAs (miRNAs) ar...
ORGANISM(S): Rattus norvegicus 
2015-06-04 | E-GEOD-54028 | biostudies-arrayexpress
TranscriptomicsThe expression profiles of 82 novel and 245 known human imsRNAs
The expression profiling of 245 known and 82 novel imsRNAs (intermediate-size noncoding RNAs, 50-500nt, which were identified from human fetal brain tissue) across different human fetal tissues (brain, heart, liver, lung and spleen at the 24-week gestation stage), different fetal brain gestational s...
ORGANISM(S): Homo sapiens 
2010-12-21 | E-GEOD-26196 | biostudies-arrayexpress
ProteomicsSUN5 interacts with nuclear membrane LaminB1 and cytoskeletal GTPase Septin12 mediating the sperm head-and-tail junction
Acephalic spermatozoa syndrome (ASS) is a severe teratospermia with decaudated, decapitated and malformed sperm, resulting in male infertility. Nuclear envelop (NE) protein SUN5 localizes to the junction between the sperm head and tail. Mutations in SUN5 gene have been identified most frequently (33...
ORGANISM(S): Mus Musculus 
2024-05-20 | PXD051278 |
TranscriptomicsDeep profiling of the novel intermediate-size noncoding RNAs in intraerythrocytic Plasmodium falciparum
Intermediate-size noncoding RNAs (is-ncRNAs) have been shown to play important regulatory roles in the development of several eukaryotic organisms. However, they have not been thoroughly explored in Plasmodium falciparum, which is the most virulent malaria parasite infecting human being. By using Il...
ORGANISM(S): Plasmodium falciparum 
2014-03-30 | E-GEOD-45172 | biostudies-arrayexpress
ProteomicsProteomics analysis of the myocardium form chronic hypobaric hypoxia-induced mice model
C57BL/6J mice were assigned to the hypobaric hypoxia chamber for simulation of high-altitude conditions. iTRAQ proteomics analysis/nanoUHPLC-MS/MS analysis was performed accordingly in the right myocardium of mice that had been allowed to develop hypoxia-induced pulmonary hypertension after hypobari...
ORGANISM(S): Mus Sp. 
2023-02-23 | PXD040342 |
ProteomicsComparative Proteomics Reveals Physiological and Molecular Mechanisms Underlying Sour Jujube Resistance to Jujube Witches' Broom Disease
Jujube is an important medicinal plant and economic crop in China. However, long-term infestation by jujube witches’ broom disease has led to significant yield losses. In this study, TMT-based quantitative proteomics was employed to investigate the molecular mechanisms underlying disease resistance...
ORGANISM(S): Ziziphus Jujuba Var. Spinosa 
2026-02-07 | PXD074213 |
ProteomicsA BioID-mediated proximity-labeling of human DTX2
To identify human DTX2 proximal proteome, the BioID-DTX2 fusion protein was expressed in DTX2 KO HeLa cells. The biotinylated proteins were pulled down and subjected to mass spectrometry analysis.
ORGANISM(S): Homo Sapiens 
2022-10-11 | PXD023795 |
ProteomicsIdentifying glycolysis in mitochondria as a new perspective on the pathogenesis of retinitis pigmentosa
The interaction proteins were obtained by immunoprecipitation (IP) of VWA8 using retinal pigment epithelium cell lysate.
ORGANISM(S): Homo Sapiens 
2026-03-29 | PXD076332 |
ProteomicsSerum peptidomic screening identified circulating peptide biomarkers
Background: Reliable biomarkers are needed to improve preeclampsia (PE) prediction accuracy. With the investigational tool of peptidomics, we aimed to identify and validate potential serum peptide biomarkers in cohorts suspected for PE development in middle or late pregnancy. Methods: Totally 195 se...
ORGANISM(S): Homo Sapiens 
2022-05-26 | PXD034147 |
ProteomicsDissection of Blood Ecosystem in SARS-CoV-2 Omicron Patients
Here, we systematically profiled clinical phenomes, transcriptomes, proteomes, metabolomes, and immune repertoire of blood cells or plasma in over 1000 specimens from SARS-CoV-2 Omicron patients across multiple disease phases.
ORGANISM(S): Homo Sapiens 
2024-08-02 | PXD045174 |
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