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MetabolomicsMetabolic Reprogramming and Reliance in Human Skin Wound Healing
Impaired skin wound healing is a significant global health issue, especially among the elderly. Wound healing is a well-orchestrated process involving the sequential phases of inflammation, proliferation, and tissue remodeling. Although wound healing is a highly dynamic and energy-requiring process,...
2024-07-02 | MTBLS3315 | MetaboLights
MetabolomicsMitochondrial respiration controls neoangiogenesis during wound healing and tumour growth

The vasculature represents a highly plastic compartment, capable of switching from a quiescent to an active proliferative state during angiogenesis. Metabolic reprogramming in endothelial cells (ECs) thereby is crucial to cover the increasing cellular energy demand under growth conditions. Here w...

2020-06-29 | MTBLS1764 | MetaboLights
MetabolomicsNi-MOFs as a Simple and Effective Nanomedicine for ROS-Mediated Antibacterial Wound Healing via a Themoelectrocatalytic Process

Thermoelectrocatalytic nickel-based metal-organic frameworks (Ni-MOFs) autonomously generate reactive oxygen species (ROS) via human body-ambient temperature differences. They exhibit potent antibacterial activity against wound-infecting pathogens, and effectively promote infected skin wound heal...

2026-03-13 | MTBLS14045 | MetaboLights
MetabolomicsFree fatty acid generation via Rhein-induced LDL-C endocytosis accelerates biofilm infected diabetic wound healing

Diabetic foot infection (DFI) significantly increases risks of hospitalization and amputation, with biofilm infections caused by methicillin-resistant Staphylococcus aureus (MRSA) and carbapenem-resistant Enterobacteriaceae (CRE) being key drivers of treatment failure. Here, we analyze MRSA/CRE b...

2026-01-06 | MTBLS13611 | MetaboLights
MetabolomicsFree fatty acid generation via Rhein-induced LDL-C endocytosis accelerates biofilm infected diabetic wound healing

Diabetic foot infection (DFI) significantly increases risks of hospitalization and amputation, with biofilm infections caused by methicillin-resistant Staphylococcus aureus (MRSA) and carbapenem-resistant Enterobacteriaceae (CRE) being key drivers of treatment failure. Here, we ana...

2026-01-06 | MTBLS13603 | MetaboLights
MetabolomicsPostoperative Exercise Modulating Gut Microbiota and Associated Metabolites to Facilitate Bone-Tendon Healing in Rotator Cuff Tears

Background: Rotator cuff tear (RCT) is a prevalent shoulder injury, and postoperative exercise is considered to facilitate RCT healing. However, the effect of postoperative exercise on RCT healing through gut microbiota and metabolites remains unclear.

Method: The control (con) group (n=10...

2026-03-03 | MTBLS13894 | MetaboLights
MetabolomicsCoupling Inflammatory Resolution to Osteogenesis: Lymphatic Vessels as Stage-specific Niche Regulators in Skeletal Healing

Skeletal healing requires the coordinated resolution of inflammation and precise lineage commitment of mesenchymal progenitors, yet the mechanisms coupling these processes remain incompletely defined. Here, we reveal that lymphatic vessels in bone serve as dynamic orchestrato...

2026-01-17 | MTBLS13645 | MetaboLights
MetabolomicsA Randomized Controlled Trial of Shengji Ointment Combined with Bromelain in Promoting Healing of Tendon-Exposed Diabetic Foot Wounds: Metabolomics Profiling Analysis

Background: Diabetic foot tendon exposures are prone to infection, necrosis, and prolonged treatment cycles, not only hindering wound healing but potentially leading to amputation and life-threatening complications. Shengji ointment combined with bromelain has demonstrated preliminary efficacy i...

2025-07-14 | MTBLS12713 | MetaboLights
ProteomicsUsing Quantitative Proteomic Assessments and their Association with Long Term Healing Outcomes
Healing after Achilles tendon rupture (ATR) is protracted with high individual variation and unsatisfactory outcome. Biomarkers prognostic of healing are unknown while physical and mechanical factors are used for predicting long-term healing outcomes in clinics today. The present study was designed ...
ORGANISM(S): Homo sapiens (Human) 
2022-05-25 | PXD029202 | Pride
Outcome Proteomics Mass spectrometry Healing Achilles tendon rupture Biomarkers 
TranscriptomicsTranscription profiling by array of excisional biopsy wounds from young and old human subjects to measure the influence of age on cutaneous wound healing
The aim of this experiment was measure the influence of age on cutaneous wound healing using human subjects. Increaded age has been associated with delayed wound healing in mouse models and in humans. Gene expression was compared between excisional biopsy wounds from young and old subjects.
ORGANISM(S): Homo sapiens 
2008-04-10 | E-MEXP-1074 | biostudies-arrayexpress
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