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TranscriptomicsTranscription profiling of Arabidopsis plants after heat shock or treatment with HSP90 inhibitors (geldanamycin and radicicol)
Effect of heat shock or HSP90 inhibitors (geldanamycin and radicicol) on wild type Arabidopsis thaliana.
ORGANISM(S): Arabidopsis thaliana 
2007-06-01 | E-ATMX-12 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human adult T cell leukemia cell lines to investigate the biological pathways of Hsp90 inhibitors
Heat shock protein 90 (Hsp90) is essential for the stability and the function of many client proteins, such as ERB2, C-RAF, CDK4, HIF-1 aplha and AKT. Recent reports demonstrated that inhibition of Hsp90 modulates multiple functions required for survival of human cancer, such as myeloma (Mitsiades e...
ORGANISM(S): Homo sapiens 
2009-06-08 | E-GEOD-12287 | biostudies-arrayexpress
TranscriptomicsBioligical pathways and in vitro anti-proliferative activity of Hsp90 inhibition in adult T cell leukemia cells
Background. Heat shock protein 90 (Hsp90) is essential for the stability and the function of many client proteins, such as ERB2, C-RAF, CDK4, HIF-1 aplha and AKT. Recent reports demonstrated that inhibition of Hsp90 modulates multiple functions required for survival of human cancer, such as myeloma...
ORGANISM(S): Homo sapiens 
2009-05-27 | E-GEOD-12257 | biostudies-arrayexpress
ProteomicsQuantification of calcyclin and heat shock protein 90 in sera from women with and without preeclampsia by mass spectrometry
Maternal serum levels of calcyclin and heat shock protein 90 were compared throughout pregnancy from the first trimester till term among women with preeclampsia (PE) and age-matched normotensive pregnant controls (C). Serum samples from two different studies, a nested case-control study embedded in ...
ORGANISM(S): Homo sapiens (Human) 
2018-11-21 | PXD009025 | Pride
Hsp90 S100a6 Prm Serum Preeclampsia Placenta 
ProteomicsHSP90 promotes Burkitt lymphoma cell survival by maintaining tonic B cell receptor signaling
Burkitt’s lymphoma (BL) is an aggressive B-cell neoplasm that is currently treated by intensive chemotherapy in combination with anti-CD20 antibodies. Because of their toxicity, current treatment regimens are often not suitable for elderly patients or for patients in developing countries where BL is...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-29 | MSV000080781 | MassIVE
ProteomicsCharacterizations of HSP90-interacting complex in renal cells using tandem affinity purification and its potential role in kidney stone formation
Heat shock protein 90 (HSP90) is a highly abundant molecular chaperone that interacts with many other intracellular proteins to regulate various cellular processes. However, compositions of the HSP90-interacting complex remain underinvestigated. This study thus aimed to characterize such complex in ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2018-12-17 | MSV000083252 | MassIVE
Proteomicsc-Abl Dependent Tyrosine Phosphorylation of theCo-chaperone Aha1 Regulates Interaction with Hsp90
The ability of Heat Shock Protein 90 (Hsp90) to hydrolyze ATP is essential for its chaperone function. The co-chaperone Aha1 stimulates Hsp90 ATPase activity tailoring the chaperone function to specific “client” proteins. The intracellular signaling mechanisms directly regulating Aha1 association wi...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-28 | MSV000080713 | MassIVE
TranscriptomicsHDAC6 and HSP90 control the functions of Foxp3+ T regulatory cells
Foxp3+ T-regulatory cells (Tregs) are key to immune homeostasis such that their diminished numbers or function can cause autoimmunity and allograft rejection. Foxp3+ Tregs express histone/protein deacetylases (HDACs) that regulate chromatin remodeling, gene expression and protein function. Pan-HDAC ...
ORGANISM(S): Mus musculus 
2011-05-01 | E-GEOD-27896 | biostudies-arrayexpress
GenomicsHeat-shock protein 90 globally targets paused promoters and regulates environment-induced gene expression
In this study we provide evidence that Hsp90 binds chromatin at specific sites close to several TSS in Drosophila S2 cell line. In addition of finding a preference for stalled promoter regions of annotated genes, we uncover many intergenic Hsp90 binding sites coinciding with non-annotated transcript...
ORGANISM(S): Drosophila melanogaster 
2012-05-14 | E-GEOD-31226 | biostudies-arrayexpress
ProteomicsJin_Context_dependent_interactions_between_HSP90_and_kinase_clientele
This submission consists of the mass spectrometry raw files for the manuscript by Jin et al. (Mutational analysis of GSK3B protein kinase together with kinome-wide binding and stability studies suggest context-dependent recognition of kinases by the chaperone HSP90). This submission contains files f...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2016-01-06 | MSV000079445 | MassIVE
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