Heavy water metabolic labeling

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Proteomics (64)
Transcriptomics (44)
Unknown (23)
Metabolomics (4)
Genomics (1)

Organisms

Andropogon gerardi (63)
Bacteria (63)
Bartonella quintana JK 31 (63)
Canis lupus familiaris (63)
Clavibacter nebraskensis NCPPB 2581 (63)
Mus musculus (8)
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uncultured bacterium (1)
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Repository

pride (63)
biostudies-arrayexpress (44)
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Disease

Chronic kidney disease (3)
Chronic kidney disease (3)
Decreased fumarate hydratase activity (3)
Breast cancer (2)
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Alzheimer's disease (1)
Buruli ulcer disease (1)
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Disease free (1)
Fatty liver disease (1)
Lung cancer (1)
Mitochondrial metabolism disease (1)
Myocardial ischemia (1)
Nonalchoholic fatty liver disease 1 (1)
Systolic heart failure (1)
Type 2 diabetes mellitus (1)

Technology Type

Mass Spectrometry (63)
Shotgun proteomics (45)
Bottom-up proteomics (7)
Affinity purification coupled with mass spectrometry proteomics (6)
Gel-based experiment (6)
Mass spectrometry (3)
Data-dependent acquisition (3)
Proteogenomics (3)
Chemical cross-linking coupled with mass spectrometry proteomics (2)
Mass spectrometry assay (1)
Data-independent acquisition (1)
Top-down proteomics (1)

Instrument Platform

ScanArray Lite [PerkinElmer] (1)
418 [Affymetrix] (1)
GenePix 4000B [Axon Instruments] (1)
Axon GenePix 4000B scanning hardware (1)
Illumina NovaSeq 6000 (1)
6540 Q-TOF LC/MS (Agilent) (1)
Gas Chromatography MS - (1)
Liquid Chromatography MS - negative - reverse-phase (1)
Liquid Chromatography MS - negative - reverse phase (1)
Liquid Chromatography MS - positive - reverse phase (1)

Publication Date

2018 (12)
2021 (9)
2017 (8)
2025 (8)
2010 (7)
2026 (6)
2016 (6)
2015 (6)
2007 (6)
2020 (6)
2014 (5)
2008 (5)
2024 (4)
2023 (4)
2022 (4)
2019 (4)
2013 (3)
2012 (3)
2009 (3)
2005 (3)

CHEBI ID

CHEBI:87798 (1)
CHEBI:37624 (1)
CHEBI:29985 (1)
CHEBI:17115 (1)
CHEBI:15428 (1)
CHEBI:27551 (1)
CHEBI:16027 (1)
CHEBI:17203 (1)
CHEBI:30769 (1)
CHEBI:15727 (1)
CHEBI:17345 (1)
CHEBI:44897 (1)
CHEBI:16708 (1)
CHEBI:17821 (1)
CHEBI:16643 (1)
CHEBI:16695 (1)
CHEBI:229503 (1)
CHEBI:229499 (1)
CHEBI:229498 (1)
CHEBI:229497 (1)
CHEBI:229493 (1)
CHEBI:229500 (1)
CHEBI:229494 (1)
CHEBI:229501 (1)
CHEBI:229502 (1)
CHEBI:229495 (1)
CHEBI:229496 (1)
CHEBI:199577 (1)

Metabolite Name

<small>L</small>-serine (1)
<small>L</small>-methionine (1)
Cytidine 5'-monophosphate disodium salt (1)
Uridylic acid (1)
L-Glutamic acid, ion(1-) (1)
Hydrazine (1)
L-Glucose (1)
Hydroxylamine (1)
Methanol (1)
Adenosine 5'-monophosphate (1)
Phosphoenolpyruvate (1)
Thymine (1)
Glycine (1)
Citrate (1)
Beta-Alanine (1)
Ethanol (1)
Carnosine (1)
Ethanolamine (1)
Formic acid (1)
Acetic acid (1)
Propionic acid (1)
L-proline (1)
Adenine (1)
Glycine (1)
GMP (1)
5-methylcytosine (1)
D-Lac-Hcy (1)
D-Lac-Gln (1)
D-Lac-Phe (1)
D-Lac-Thr (1)

First Public Date

2026 (1)

Modification

4x(15)N labeled L-arginine (3)
4x(2)H labeled dimethylated L-lysine (2)
2x(15)N labeled L-lysine (1)

Study type

Transcription profiling by array (42)
Other (1)
RNA-seq of coding RNA (1)

Release Date

2010 (7)
2016 (6)
2007 (6)
2023 (6)
2008 (5)
2014 (4)
2009 (4)
2022 (4)
2015 (3)
2013 (3)
2012 (3)
2005 (3)
2020 (3)
2018 (2)
2025 (2)
2021 (2)
2026 (1)
2017 (1)
2024 (1)
2019 (1)

Lab affiliation

Department of Biochemistry and Functional Proteomics, Institute of Biology II, Faculty of Biology and BIOSS Centre for Biological Signalling Studies, University of Freiburg, 79104 Freiburg im Breisgau, Germany (4)
CRUK - Beatson Institute for Cancer Research - Switchback Rd, Bearsden, Glasgow G61 1BD - United Kingdom (3)
Yazhouwan National Laboratory, Sanya 572024, China (3)
Alkali Soil Natural Environmental Science Center, Northeast Forestry University, Harbin 150040, China (2)
Department of Neuro- and Sensory Physiology University Medical Center Göttingen Humboldtallee 23 37073 Göttingen (2)
Division of Life Science, The Hong Kong University of Science and Technology, Hong Kong SAR, China (2)
Institut Pasteur Unité des Interactions Bactéries-Cellules, Inserm U604, INRA USC2020 25 rue du Dr. Roux 75015 Paris France (2)
1Peking-Tsinghua Center for Life Sciences, Peking University, Beijing 100871, China 2Academy of Advanced Interdisciplinary Studies, Peking University, Beijing 100871, China 3Synthetic and Functional Biomolecules Center, Beijing National Laboratory for Molecular Sciences, Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China (1)
Bacteriology Department, University of Wisconsin-Madison (1)
College of Chemistry and Molecular Engineering, Peking University, Beijing, China (1)
DKFZ Heidelberg (1)
Departamento de Bioquímica y Biología Molecular B e Inmunología. Facultad de Química. Universidad de Murcia. Campus de Excelencia Mare Nostrum (1)
Department of Biochemistry and Molecular Biology, University of Calgary, Alberta, Canada; Department of Physiology and Pharmacology, University of Calgary, Alberta, Canada; The Hotchkiss Brain Institute, University of Calgary, Alberta, Canada; McCaig Institute for Bone and Joint Health, University of Calgary, Alberta, Canada (1)
Department of Cardiology, Medical University Hospital, Heidelberg, Germany (1)
Department of Chemical Biology College of Chemistry and Molecular Engineering Peking University (1)
Department of Genetics, Department of Radiation Oncology, Cancer Genomics Netherlands, Erasmus Medical Center Cancer Institute, Rotterdam, The Netherlands (1)
Department of Genome Integrity, Institute of Molecular Genetics of the Czech Academy of Sciences, Prague, Czech Republic (1)
Department of Genome Sciences University of Washington 3720 15th Ave NE Seattle WA 98195 (USA) (1)
Department of Genome Sciences, University of Washington, Seattle, WA, USA (1)
Department of Microbial Proteomics, Institute for Microbiology, University of Greifswald, Greifswald, Germany (1)
Department of Pediatrics, University of Groningen, University Medical Center Groningen (UMCG), 9713 AV Groningen, The Netherlands (1)
Department of Pharmaceutical Sciences Northeast Ohio Medical University Rootstown, OH, USA MTD project_title Proteome dynamics in dogs with heart failure (1)
Department of Plant Sciences University of Oxford South Parks Road Oxford, OX1 3RB, UK (1)
Dept Biochemistry and Biophysics, University of Pennsylvania, Philadelphia, USA (1)
Direktor Institut für Neuroanatomie und Zellbiologie Medizinische Hochschule Hannover (MHH) (1)
Division of Cardiology Johns Hopkins University School of Medicine Ross Research Building, Room 847 720 Rutland Avenue Baltimore, MD 21205 Phone: 410-614-0027 Email: dbrianfoster@jhmi.edu Web: http://web1.johnshopkins.edu/fosterlab (1)
Division of Endocrinology, Diabetes, and Metabolism, Beth Israel Deaconess Medical Center Harvard Medical School Broad Institute of Harvard and MIT (1)
Division of Physical Chemistry, Institute Ruđer Bošković, Zagreb, Croatia (1)
Faculty Director, Proteome Exploration Laboratory, Beckman Institute, California Institute of Technology, Pasadena, CA, USA (1)
Institut Gustave Roussy (1)

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D2Ome - rate constant estimation from heavy water metabolic labeling and LC-MS

We developed a software for extraction of protein decay rate constants from heavy water labeling followed by LC-MS experiments. We illustrate the program on application to normal diet and western diet fed LDLR-/- mice. We demonstrate that proteins subunits of 40S ribosomal complex have reduced stabi...

ORGANISM(S): Mus musculus (Mouse)

2019-04-10 | PXD009493 | Pride

Two-Channel Chemical Isotope Labeling Metabolomics Analysis of Human Fecal Samples

Global metabolomics study of the amine and carboxyl submetabolomes of 16 human fecal samples.

2026-09-23 | MTBLS13531 | MetaboLights

geoRge: A Computational Tool To Detect the Presence of Stable Isotope Labeling in LC/MS-Based Untargeted Metabolomics

Studying the flow of chemical moieties through the complex set of metabolic reactions that happen in the cell is essential to understanding the alterations in homeostasis that occur in disease. Recently, LC/MS-based untargeted metabolomics and isotopically labeled metabolites have been used to facil...

2015-09-15 | MTBLS213 | MetaboLights

Amino acid and heavy water labelling to obtain protein turnover rates in intact adult animals

Both labelling studies were conducted with C57/BL6J adult male mice, derived from the same supplier and maintained under identical conditions. Eleven adult male C57BL/6JOlaHsd mice (Harlan UK Ltd., Shardlow, UK) of over 12 months of age at the start of the experiment were housed individually in 48 x...

ORGANISM(S): Mus Musculus (mouse)

2021-12-13 | PXD029639 | JPOST Repository

Using Heavy Mass Isotopomers for Protein Turnover in Heavy Water Metabolic Labeling.

Not available

S-EPMC8167932 | biostudies-literature

Transcription profiling of wheat to identify genotypic differences in water soluble carbohydrate metabolism in stem

Water soluble carbohydrates (WSC, composed of mainly fructans, sucrose, glucose and fructose) deposited in wheat stems are important carbon sources for grain filling. Variation in stem WSC concentrations among wheat genotypes is one of the genetic factors influencing grain weight and yield under wat...

ORGANISM(S): Triticum aestivum

2008-10-26 | E-GEOD-9767 | biostudies-arrayexpress

Protein turnover models for LC-MS data of heavy water metabolic labeling.

Not available

S-EPMC8921656 | biostudies-literature

A metabolic labeling strategy for relative protein quantification in Clostridioides difficile

Clostridioides difficile (formerly Clostridium difficile) is a Gram-positive, spore-forming pathogen which cases drug-induced Clostridioides difficile-associated diseases in hospitals worldwide. A detailed analysis of the proteome may provide new targets for drug development or therapy strategies to...

ORGANISM(S): Peptoclostridium difficile (strain 630) (Clostridium difficile)

2018-10-25 | PXD010279 | Pride

Proteomics Relative protein quantification Mass spectrometry Metabolic labeling Clostridioides difficile

Proteome Dynamics from Heavy Water Metabolic Labeling and Peptide Tandem Mass Spectrometry.

Not available

S-EPMC7017751 | biostudies-literature

Retention Time Alignment for Protein Turnover Studies Using Heavy Water Metabolic Labeling.

Not available

S-EPMC10233748 | biostudies-literature

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136 Results

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