Sort   by:  
 Page size 
ProteomicsDevelopment of a comprehensive toxicity pathway model for 17α-ethinylestradiol in early life stage fathead minnows (Pimephales promelas)
The goal of this study is to characterize molecular toxicity pathways associated with ethinylestradiol-induced toxicity and link these molecular perturbations to apical outcomes of regulatory relevance.
ORGANISM(S): Pimephales promelas 
2021-04-09 | PXD021155 | Pride
Toxicity 17-alpha-ethinylestradiol Fathead minnows 
ProteomicsTranscriptomic points-of-departure (tPOD) derived from a 4-day rainbow trout embryo toxicity test were protective of apical effects for 17α-ethinylestradiol
There is an urgent demand for more efficient and ethical approaches in chemical risk assessment. Using 17α-ethinylestradiol (EE2) as a model compound, this study established a live-animal alternative embryo benchmark-dose (BMD) assay for rainbow trout (RBT; Oncorhynchus mykiss) to derive transcript...
ORGANISM(S): Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri) 
2021-08-17 | PXD025251 | Pride
Endocrine disruption Rainbow trout Benchmark dose Transcriptomic point-of-departure Ethinylestradiol Risk assessment 
TranscriptomicsStretch-dependent genes in vascular smooth muscle cells
Vascular smooth muscle cells (VSMCs) respond to biomechanical stretch with specific changes in gene expression which govern the phenotype of these cells. The mechanotransducer zyxin is a potential candidate for regulating the expression of such genes. Using microarrays, we compared stretch-induced ...
ORGANISM(S): Mus musculus 
2015-07-01 | E-GEOD-60447 | biostudies-arrayexpress
TranscriptomicsMicroarray data for C57BL/6J and B6.Rag2del mice after cardiomyocyte transplantation
We compared the molecular outcome following cardiomyocyte transplantation in blood and heart tissue in wildtype and T- and B cell deficient Rag2del mice. Our results demonstrate that the improved functional outcome following cardiomyocyte transplantation is dependent on a specific CCR2 macrophage re...
ORGANISM(S): Mus musculus 
2023-07-07 | E-MTAB-13152 | biostudies-arrayexpress
TranscriptomicsHigh conservation in transcriptomic and proteomic response of white sturgeon to equipotent concentrations of 2,3,7,8-TCDD, PCB 77, and benzo[a]pyrene
Adverse effects associated with exposure to dioxin-like compounds (DLCs) are mediated primarily through activation of the aryl hydrocarbon receptor (AHR). However, little is known about the cascades of events that link activation of the AHR to apical adverse effects. Therefore, this study used high-...
ORGANISM(S): Acipenser transmontanus 
2016-09-01 | E-GEOD-79624 | biostudies-arrayexpress
TranscriptomicsTranscriptome response to genistein in zebrafish embryos
To test wether endocrine disruption is detectable in zebrafish at the transcriptome level, we exposed newly fertilized zebrafish embryos to low doses of genistein (EC10 and EC20) for 48 hours. Newly fertilized embryos (<2hpf) were exposed to 2.2 mg/l (EC10) and 2.4 mg/l (EC20) genistein for 48 hours...
ORGANISM(S): Danio rerio 
2012-11-01 | E-GEOD-34616 | biostudies-arrayexpress
TranscriptomicsToxicogenomic analysis of ionic silver and silver nanoparticles on the fathead minnow and implications to human health
Nanoparticles are compounds of emerging concern with largely unknown risks for human and ecological health. It is crucial to evaluate their potential biological impact to prevent unintended adverse effects on human health and the environment. We analyzed the transcriptional effects of polyvinylpyrro...
ORGANISM(S): Pimephales promelas 
2013-11-01 | E-GEOD-46520 | biostudies-arrayexpress
Sort   by:  
 Page size