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ProteomicsN-terminome analyses of the intramembrane-cleaving protease SPPL3
The intramembrane protease SPPL3 can specifically cleave select Golgi enzymes, enabling their secretion and concomitantly altering global cellular glycosylation, yet the entire range of Golgi glycan-modifying enzymes cleaved by SPPL3 under physiological conditions remains to be defined. Here, we est...
ORGANISM(S): Homo sapiens (Human) 
2022-03-17 | PXD028769 | Pride
Hek293 Label-free Hela Sppl3 N-terminomics 
GenomicsMeCP2 binds to 5hmC enriched within active genes and accessible chromatin in the nervous system
The high level of 5-hydroxymethylcytosine (5hmC) present in neuronal genomes suggests that mechanisms interpreting 5hmC in the central nervous system (CNS) may differ from those present in embryonic stem cells. Here we present quantitative, genome-wide analysis of 5hmC, 5- methylcytosine (5mC) an...
ORGANISM(S): Mus musculus 
2013-01-14 | E-GEOD-42880 | biostudies-arrayexpress
Unknown5-hydroxymethylcytosine accumulation in postmitotic neurons results in functional demethylation of expressed genes.
Not available
S-EPMC5604027 | biostudies-literature
UnknownOxytocin modulates female sociosexual behavior through a specific class of prefrontal cortical interneurons.
Not available
S-EPMC4206218 | biostudies-literature
UnknownA Cortical Circuit for Sexually Dimorphic Oxytocin-Dependent Anxiety Behaviors.
Not available
S-EPMC5220951 | biostudies-literature
ProteomicsMuSt multiomics - Integrated multi-omics of the human gut microbiome in a case study of familial type 1 diabetes
Multiomics of faecal samples collected from individuals in families with multiple cases of type 1 diabetes mellitus (T1DM) over 3 or 4 months. Metagenomic and metatranscriptomic sequencing and metaproteomics were carried out, as well as whole human genome sequencing. Phenotypic data is available.
ORGANISM(S): mixed culture metagenome 
2016-08-22 | PXD003791 | Pride
Human microbiome Gastrointestinal Faecal Type 1 diabetes Families 
MetabolomicsIntegration of time-series meta-omics data reveals how microbial ecosystems respond to disturbance
The development of reliable, mixed-culture biotechnological processes hinges on understanding how microbial ecosystems respond to disturbances. Here we reveal extensive phenotypic plasticity and niche complementarity in oleaginous microbial populations from a biological wastewater treatment plant. W...
2021-04-06 | MTBLS2021 | MetaboLights
UnknownCell-type-specific drug-inducible protein synthesis inhibition demonstrates that memory consolidation requires rapid neuronal translation.
Not available
S-EPMC7147976 | biostudies-literature
UnknownN-terminome analyses underscore the prevalence of SPPL3-mediated intramembrane proteolysis among Golgi-resident enzymes and its role in Golgi enzyme secretion.
Not available
S-EPMC8918473 | biostudies-literature
UnknownCell-type-specific CAG repeat expansions and toxicity of mutant Huntingtin in human striatum and cerebellum.
Not available
S-EPMC10937393 | biostudies-literature
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